| Significance and problems of histopathological examination and utility of real-time reverse transcriptase-polymerase chain reaction method for the detection of sentinel lymph node metastasis in breast cancer. | |
| | |
MedLine Citation:
|
PMID: 17986798 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Sentinel lymph node (SLN) biopsy has become a common procedure for breast cancer patients. Many reported feasibility studies have revealed a high identification (95.4% of 2,125 cases) and accuracy rate on histopathological analysis (94% frozen and 97% paraffin). However, about 5 to 8% of cases false-negative are in this examination. Various methods of histopathological examination have been reported by many authors, but the Philadelphia consensus meeting recommended that sections less than 2.0 mm in thickness should be prepared and examined to detect metastasis larger than 2.0 mm. In addition, immunohistochemistry for cytokeratin is considered to be useful to detect isolated tumor cells (ITC) in the representative sections. On the other hand, real-time reverse transcriptase-polymerase chain reaction (RT-PCR) might detect micrometastasis (larger than 0.2 mm) (sensitivity and specificity; 89.5% and 96.7% frozen sections) and expected to be used as a routine method instead of histopathological examination. |
| | |
Authors:
|
Masafumi Kurosumi; Hiroyuki Takei |
Related Documents
:
|
10958508 - Principles of sentinel lymph node identification: background and clinical implications. 11343548 - Predicting the status of the nonsentinel axillary nodes: a multicenter study. 19795578 - Sentinel lymphadenectomy in breast cancer: an update on the nccn clinical practice guid... 17005598 - Lymphatic mapping and sentinel node analysis: current concepts and applications. 18097898 - The influence of social support on the duration of breast-feeding among antenatal patie... 22619638 - Usefulness of preoperative diagnosis with magnetic resonance imaging for conservative s... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Breast cancer (Tokyo, Japan) Volume: 14 ISSN: 1880-4233 ISO Abbreviation: Breast Cancer Publication Date: 2007 |
Date Detail:
|
Created Date: 2007-11-07 Completed Date: 2008-01-22 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100888201 Medline TA: Breast Cancer Country: Japan |
Other Details:
|
Languages: eng Pagination: 342-9 Citation Subset: IM |
Affiliation:
|
Department of Pathology Saitama Cancer Center, Saitama 362-0806, Japan. mkurosumi@cancer-c.pref.saitama.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Breast Neoplasms
/
pathology* Cytodiagnosis Diagnosis, Differential Humans Immunoenzyme Techniques Lymph Nodes / pathology* Lymphatic Metastasis / diagnosis Neoplasm Staging Predictive Value of Tests Reverse Transcriptase Polymerase Chain Reaction / methods* Sentinel Lymph Node Biopsy |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Increase in Fe2+-producing activity during growth of Acidithiobacillus ferrooxidans ATCC23270 on sul...
Next Document: Intraoperative imprint cytology for the diagnosis of sentinel node metastases in breast cancer.