| Significance of pre-storage leucoreduction for autologous blood. | |
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MedLine Citation:
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PMID: 19076334 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVES: To reveal the associations between cytokines in blood and transfusion-related adverse events, we studied whether pre-storage leucoreduction of autologous blood could reduce the degree of inflammatory responses, infection rates, or the duration of hospitalizations. MATERIALS AND METHODS: Patients scheduled to donate autologous blood for elective orthopaedic surgery were assigned to receive either leucoreduced (LR) or non-leucoreduced (N-LR) autologous blood based on their date of birth. Levels of cytokines in the autologous blood, values for C-reactive protein, complete blood count and body temperature of the patients, as well as adverse clinical events, were evaluated periodically. RESULTS: Four hundred patients entered this study (LR group: 196, N-LR group: 204). The production of cytokines, excluding interleukin 1beta (IL-1beta), was suppressed for the LR group. However, for unknown reasons, IL-1beta actually increased during storage for the LR group. There were no differences between the two groups in the length of hospital stay, postoperative C-reactive protein changes, leucocyte count, or body temperature, and no clinical problems associated with blood transfusion were observed in either group. CONCLUSION: Pre-storage leucoreduction for autologous blood may be effective to suppress cytokine accumulation. However, clinical benefits such as prevention of febrile non-haemolytic reactions could not be demonstrated. |
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Authors:
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T Tasaki; H Ohto; S Sasaki; T Kanno; T Igari; Y Hoshi |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-12-05 |
Journal Detail:
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Title: Vox sanguinis Volume: 96 ISSN: 1423-0410 ISO Abbreviation: Vox Sang. Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-06-15 Completed Date: 2009-09-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0413606 Medline TA: Vox Sang Country: England |
Other Details:
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Languages: eng Pagination: 226-33 Citation Subset: IM |
Affiliation:
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Blood Transfusion Service, Tokyo Jikei University Hospital, 3-19-18 Nishi-Shimbashi, Minato-ku, Tokyo, Japan. ttasaki@jikei.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Transfusion, Autologous* C-Reactive Protein / analysis Cytokines / blood Female Humans Infection Control* Length of Stay Leukocyte Reduction Procedures* Male Retrospective Studies Surgical Procedures, Elective |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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