Document Detail


Significance of postprandial symptom exacerbation in hypertrophic cardiomyopathy.
MedLine Citation:
PMID:  20346318     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients with hypertrophic cardiomyopathy (HC) can experience exacerbation of exertional symptoms after a meal. The present study was designed to determine the prevalence and clinical correlates of postprandial symptom exacerbation (PPSE) in patients with HC. The records of 558 patients with HC and PPSE data who had undergone echocardiography at our institution from 2002 to 2006 were reviewed. Continuous-wave Doppler velocities were used to determine the left ventricular outflow tract gradient. Left ventricular filling was assessed using transmitral velocity curves. The Minnesota Living With Heart Failure questionnaire was administered to measure symptom limitations. A multivariate regression model was developed to determine the independent correlates with PPSE. Of the 558 patients whose records were reviewed, 189 (33.8%) had PPSE. The patients with PPSE were more likely to experience New York Heart Association class III/IV dyspnea or presyncope. PPSE was associated with greater resting outflow gradients and lower perceived quality of life. In conclusion, patients presenting with severe postprandial symptoms and reduced quality of life should be carefully evaluated for the presence of dynamic left ventricular outflow tract obstruction.
Authors:
Jonathon C Adams; Steve R Ommen; Kyle W Klarich; A Jamil Tajik; Rick A Nishimura
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Publication Detail:
Type:  Journal Article     Date:  2010-02-13
Journal Detail:
Title:  The American journal of cardiology     Volume:  105     ISSN:  1879-1913     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-29     Completed Date:  2010-04-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  990-2     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Affiliation:
Division of Cardiovascular Diseases, Mayo Clinic, Scottsdale, Arizona.
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MeSH Terms
Descriptor/Qualifier:
Cardiomyopathy, Dilated / complications,  physiopathology*
Echocardiography, Doppler
Female
Humans
Male
Middle Aged
Postprandial Period
Questionnaires
Ventricular Dysfunction, Left / etiology,  ultrasonography*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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