Document Detail

Significance of plasma nitric oxide/endothelial-1 ratio for prediction of coronary artery disease.
MedLine Citation:
PMID:  15889192     Owner:  NLM     Status:  MEDLINE    
Vascular tone is regulated by vasodilators and vasoconstrictors. Endothelin-1 (ET-1) is the predominant vasoconstrictor peptide that constricts vascular smooth muscle, whereas nitric oxide (NO) is the primary vasodilator peptide that relaxes vascular smooth muscle. In this study, the authors examined whether NO/ET-1 ratio is a useful marker for detecting coronary artery disease (CAD), by comparison with evaluation based on vascular endothelial (VE) function. They measured plasma NOX and ET-1 by using ENO-200 and radioimmunoassay, in 38 subjects with normal (NL) coronary arteries (NL group; mean age, 60 +/-12 years) and 25 subjects with CAD (CAD group; mean age, 69 +/- 6 years). VE function (randomized endothelium-dependent [D] and endothelium-independent [I] VE function) was assessed by measuring brachial artery (BA) diameter by using high-resolution ultrasound (7.5 MHz). Soon after these procedures, symptom-limited exercise testing was performed. There were no statistically significant differences in serum lipid concentrations or VED function between the groups. However, the CAD group had a significantly lower NO/ET-1 ratio (1.2 +/- 1.1 vs 2.7 +/- 2.2, p < 0.01) and BA diameter after sublingual nitroglycerin (VEID function: 6 +/- 7% vs 10 +/- 4%, p < 0.05). As expected, the ST segment and treadmill exercise duration were significantly lower in the CAD group. Sensitivity and specificity for detecting CAD by plasma NO/ET-1 ratio (> or =2 .0) were 90% and 85%, respectively; sensitivity and specificity for detecting CAD by ST depression (> or =1 mm) were 80% and 78%, respectively. The present results suggest that plasma NO/ET-1 ratio is a useful biological marker for predicting CAD.
Akira Kurita; Takemi Matsui; Toshiaki Ishizuka; Bonpei Takase; Kimio Satomura
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Angiology     Volume:  56     ISSN:  0003-3197     ISO Abbreviation:  Angiology     Publication Date:    2005 May-Jun
Date Detail:
Created Date:  2005-05-12     Completed Date:  2005-06-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  259-64     Citation Subset:  IM    
Department of Biomedical Engineering and Internal Medicine, National Defensse Medical College, Saitma, Japan.
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MeSH Terms
Biological Markers / blood*
Brachial Artery / ultrasonography
Coronary Artery Disease / blood*,  diagnosis
Endothelin-1 / blood*
Endothelium, Vascular / physiology
Exercise Test
Lipids / blood
Middle Aged
Nitric Oxide / blood*
Sensitivity and Specificity
Reg. No./Substance:
0/Biological Markers; 0/Endothelin-1; 0/Lipids; 10102-43-9/Nitric Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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