| Significance of plasma N-terminal pro-brain natriuretic peptide in patients with systemic sclerosis-related pulmonary arterial hypertension. | |
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MedLine Citation:
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PMID: 14635979 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: A single centre pilot study to investigate the role of the plasma N-terminal pro-brain natriuretic peptide (N-T proBNP) assay to risk stratify patients with suspected pulmonary arterial hypertension (PAH) from a background SSc population. METHODS: Out of 49 SSc patients, 23 had and 26 did not have PAH. Right ventricular haemodynamic variables, six-minute walk test and plasma N-T proBNP levels were recorded from patients catheterised for suspected PAH (23 with PAH and 11/26 without PAH). RESULTS: Mean value of N-T proBNP for SSc patients with PAH was 3365 (standard error 1095) pg/ml compared to 347 (174) pg/ml for patients without PAH. There was a statistically significant correlation (P < 0.05) between N-T proBNP values and (i) mean pulmonary artery pressure (r = 0.53), (ii) right ventricular end diastolic pressure (r = 0.59) and (iii) pulmonary vascular resistance (r = 0.49). Receiver operator characteristic curve analysis showed that a cut-off value of 395.34 pg/ml had a sensitivity of 0.69 and specificity of 1.0. CONCLUSIONS: N-T proBNP estimation in systemic sclerosis-related pulmonary hypertension is a potentially useful diagnostic tool with a high specificity and negative predictive value. This test has the potential to have an important role in risk stratification and monitoring of therapy in the future. |
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Authors:
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D Mukerjee; L B Yap; A M Holmes; D Nair; P Ayrton; C M Black; J G Coghlan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Respiratory medicine Volume: 97 ISSN: 0954-6111 ISO Abbreviation: Respir Med Publication Date: 2003 Nov |
Date Detail:
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Created Date: 2003-11-25 Completed Date: 2004-01-15 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8908438 Medline TA: Respir Med Country: England |
Other Details:
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Languages: eng Pagination: 1230-6 Citation Subset: IM |
Affiliation:
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Royal Free Campus, Centre for Rheumatology, Pond Street, Rowland Hill Street, London NW32QG, UK. devmukerjee@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Atrial Natriuretic Factor / blood* Exercise / physiology Female Hemodynamics / physiology Humans Hypertension, Pulmonary / blood, complications, diagnosis*, physiopathology Male Middle Aged Pilot Projects Protein Precursors / blood* ROC Curve Risk Factors Scleroderma, Systemic / blood*, complications, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/N-terminal proatrial natriuretic peptide; 0/Protein Precursors; 85637-73-6/Atrial Natriuretic Factor |
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