Document Detail

Significance of plasma N-terminal pro-brain natriuretic peptide in patients with systemic sclerosis-related pulmonary arterial hypertension.
MedLine Citation:
PMID:  14635979     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: A single centre pilot study to investigate the role of the plasma N-terminal pro-brain natriuretic peptide (N-T proBNP) assay to risk stratify patients with suspected pulmonary arterial hypertension (PAH) from a background SSc population. METHODS: Out of 49 SSc patients, 23 had and 26 did not have PAH. Right ventricular haemodynamic variables, six-minute walk test and plasma N-T proBNP levels were recorded from patients catheterised for suspected PAH (23 with PAH and 11/26 without PAH). RESULTS: Mean value of N-T proBNP for SSc patients with PAH was 3365 (standard error 1095) pg/ml compared to 347 (174) pg/ml for patients without PAH. There was a statistically significant correlation (P < 0.05) between N-T proBNP values and (i) mean pulmonary artery pressure (r = 0.53), (ii) right ventricular end diastolic pressure (r = 0.59) and (iii) pulmonary vascular resistance (r = 0.49). Receiver operator characteristic curve analysis showed that a cut-off value of 395.34 pg/ml had a sensitivity of 0.69 and specificity of 1.0. CONCLUSIONS: N-T proBNP estimation in systemic sclerosis-related pulmonary hypertension is a potentially useful diagnostic tool with a high specificity and negative predictive value. This test has the potential to have an important role in risk stratification and monitoring of therapy in the future.
D Mukerjee; L B Yap; A M Holmes; D Nair; P Ayrton; C M Black; J G Coghlan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Respiratory medicine     Volume:  97     ISSN:  0954-6111     ISO Abbreviation:  Respir Med     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-25     Completed Date:  2004-01-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8908438     Medline TA:  Respir Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  1230-6     Citation Subset:  IM    
Royal Free Campus, Centre for Rheumatology, Pond Street, Rowland Hill Street, London NW32QG, UK.
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MeSH Terms
Aged, 80 and over
Atrial Natriuretic Factor / blood*
Exercise / physiology
Hemodynamics / physiology
Hypertension, Pulmonary / blood,  complications,  diagnosis*,  physiopathology
Middle Aged
Pilot Projects
Protein Precursors / blood*
ROC Curve
Risk Factors
Scleroderma, Systemic / blood*,  complications,  physiopathology
Reg. No./Substance:
0/N-terminal proatrial natriuretic peptide; 0/Protein Precursors; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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