| Significance of the perfusion-diffusion mismatch in chronic cerebral ischemia. | |
| | |
MedLine Citation:
|
PMID: 16941614 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: To determine whether the perfusion deficit could predict brain infarction in patients with chronic cerebral ischemia who experienced recurring episodes of neurological symptoms and showed a perfusion-diffusion mismatch on magnetic resonance (MR) images. MATERIALS AND METHODS: In 53 consecutive patients (38 males and 15 females, 62+/-13 years old) with ischemia in the middle cerebral artery (MCA) territory, lesion volumetry was performed on parametric maps of the time-to-peak, the cerebral blood volume, and diffusion-weighted (DW) images. The infarct lesions were assessed on follow-up T2-weighted (T2W) MR images after eight days. Cerebrovascular changes were determined by time-of-flight (TOF) MR angiography (MRA). Inferential and correlation statistics were used. RESULTS: Patients with chronic ischemic brain disease (N=39) who presented with a severe perfusion-diffusion mismatch in the presence of a normal cerebral blood volume had no or small brain infarctions as found on follow-up T2W images. MRA revealed widespread abnormalities of the basal cerebral arteries compatible with brain perfusion abnormalities. In contrast, in acute stroke patients (N=14) the deficit of cerebral perfusion predicted the infarct lesion in the T2W images. CONCLUSION: Our results suggest that in chronic cerebral ischemia the normal blood volume was maintained despite the depression of cerebral perfusion and recurring minor insults. |
| | |
Authors:
|
Irina Surikova; Stefanie Meisel; Mario Siebler; Hans-Jörg Wittsack; Rüdiger J Seitz |
Related Documents
:
|
9548134 - Low-field magnetic resonance imaging of the canine stifle joint: normal anatomy. 8010214 - Mr angiography of normal pelvic arteries: comparison of signal intensity and contrast-t... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of magnetic resonance imaging : JMRI Volume: 24 ISSN: 1053-1807 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2006 Oct |
Date Detail:
|
Created Date: 2006-09-28 Completed Date: 2007-01-23 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
|
Languages: eng Pagination: 771-8 Citation Subset: IM |
Copyright Information:
|
Copyright (c) 2006 Wiley-Liss, Inc. |
Affiliation:
|
Department of Neurology, Heinrich Heine University, Düsseldorf, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Blood Flow Velocity / physiology Brain Ischemia / physiopathology* Cerebral Infarction / physiopathology* Cerebrovascular Circulation / physiology Contrast Media Diffusion Magnetic Resonance Imaging* Female Gadolinium DTPA / diagnostic use Humans Magnetic Resonance Angiography* Male Middle Aged Predictive Value of Tests Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
|
0/Contrast Media; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clinical response of patients with sickle cell anemia to cromolyn sodium nasal spray.
Next Document: Increased circulating platelet-neutrophil, platelet-monocyte complexes, and platelet activation in p...