| Significance of peptidoglycan, a proinflammatory bacterial antigen in atherosclerotic arteries and its association with vulnerable plaques. | |
| | |
MedLine Citation:
|
PMID: 12106839 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Peptidoglycan (PG) is a major component of the cell wall of gram-positive bacteria that is abundantly present in all human mucosa. PG is a functional lipopolysaccharide analog that binds to CD14 on macrophages and induces proinflammatory cytokine production and metalloproteinases. We investigated the hypothesis that bacterial PG is present in atherosclerotic tissue. In addition, plaque phenotypes were characterized in relation to presence of PG. Immunohistology of carotid (n = 15) and femoral (n = 6) endarterectomy specimens revealed the presence of PG in the cytoplasm of cells located in plaques. PG was detected in 14 of 15 carotid arteries and 5 of 6 femoral arteries. From the 14 coronary arteries, 31 atherosclerotic segments were selected. PG was detected within 19 of 31 of these coronary segments. Western blot demonstrated the presence of the toll-like receptor (TLR-2), the co-receptor for PG, in coronary artery tissue. The number of PG-containing cells in coronary arteries was significantly higher when the histologic features of plaque vulnerability were evident. Inflammation of the cap or shoulder was observed in 11 of 19 PG-positive versus 2 of 12 PG-negative segments (p = 0.023). More than 50% of the plaque area consisted of atheroma in 7 of 19 PG-positive segments and 0 of 12 PG-negative segments (p = 0.025). Heavy smooth muscle cell staining occurred in the plaque cap and shoulder in 3 of 19 PG-positive segments versus 9 of 12 PG-negative segments. Proinflammatory bacterial PG and its co-receptor have been observed in atherosclerotic arteries, in association with the vulnerable plaque phenotype. |
| | |
Authors:
|
Jon D Laman; Arjan H Schoneveld; Frans L Moll; Marjan van Meurs; Gerard Pasterkamp |
Related Documents
:
|
19662229 - Changes in hyaluronan metabolism and rhamm receptor expression accompany formation of c... 17880329 - Angiographic no-reflow phenomenon and plaque characteristics by virtual histology intra... 16875309 - Preoperative extracranial carotid artery examination with ultrasonography in patients u... 12410519 - Photodynamic therapy: applications in atherosclerotic vascular disease with motexafin l... 9415849 - Morphology of chronic coronary occlusions and response to interventional therapy--a stu... 19654939 - Atherosclerotic progression attenuates the expression of nogo-b in autopsied coronary a... 21735529 - Transcatheter closure of an iatrogenic aorto-right ventricular fistula. 10821099 - Cerebrospinal fluid drainage to reverse paraplegia after endovascular thoracic aortic a... 21099579 - Abciximab treatment modalities for thromboembolic events related to aneurysm coiling. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The American journal of cardiology Volume: 90 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2002 Jul |
Date Detail:
|
Created Date: 2002-07-10 Completed Date: 2002-08-16 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
|
Languages: eng Pagination: 119-23 Citation Subset: AIM; IM |
Affiliation:
|
Department of Immunology, Erasmus University Rotterdam and University Hospital Rotterdam, Dijkzigt, The Netherlands. laman@immu.fgg.eur.nl |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Cadaver Carotid Arteries / pathology Coronary Artery Disease / microbiology*, pathology Drosophila Proteins* Endarterectomy Female Femoral Artery / pathology Gram-Positive Bacteria / immunology*, pathogenicity* Humans Male Membrane Glycoproteins / isolation & purification Peptidoglycan / isolation & purification* Phenotype Receptors, Cell Surface / isolation & purification Toll-Like Receptor 2 Toll-Like Receptors |
| Chemical | |
Reg. No./Substance:
|
0/Drosophila Proteins; 0/Membrane Glycoproteins; 0/Peptidoglycan; 0/Receptors, Cell Surface; 0/TLR2 protein, human; 0/Toll-Like Receptor 2; 0/Toll-Like Receptors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: One-year outcome after percutaneous coronary intervention for stable and unstable angina pectoris wi...
Next Document: Effect of exercise on upper and lower extremity endothelial function in patients with coronary arter...