Document Detail


Significance of para-esophageal lymph nodes in food or aeroallergen-induced iNKT cell-mediated experimental eosinophilic esophagitis.
MedLine Citation:
PMID:  22207581     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Eosinophilic esophagitis (EoE) is a recently recognized inflammatory disorder driven by food hypersensitivity; however, the specific foods and mechanisms involved are unclear. In patients with EoE, we have found that hypersensitivities to corn and peanuts are the most common. Accordingly, we sensitized and exposed mice either intranasally or intragastrically with corn or peanut extract or saline. Esophageal eosinophilia, the genes of eosinophil-directed cytokines, and allergen-induced antibodies were examined in mice challenged with corn or peanut extract or saline. A high number of esophageal lamina propria eosinophils as well as eosinophilic microabscesses, intraepithelial eosinophils, extracellular eosinophilic granules, thickened and disrupted epithelial mucosa, and mast cell hyperplasia were observed in the esophagus of peanut or corn allergen-challenged mice. Mechanistic analysis indicated that para-esophageal lymph nodes might be critical in the trafficking of eosinophils to the esophagus and in EoE association to airway eosinophilia. Furthermore, experimentation with gene-targeted mice revealed that peanut allergen-induced EoE was dependent on eotaxin and invariant natural killer T (iNKT) cells, as CD1d and eotaxin-1/2 gene-deficient mice were protected from disease induction. Thus we provide evidence that para-esophageal lymph nodes are involved in food- or aeroallergen-induced eosinophilia and patchy EoE pathogenesis, likely a mechanism dependent on eotaxins and iNKT cells.
Authors:
Priya Rajavelu; Madhavi Rayapudi; Matthew Moffitt; Akanksha Mishra; Anil Mishra
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-12-29
Journal Detail:
Title:  American journal of physiology. Gastrointestinal and liver physiology     Volume:  302     ISSN:  1522-1547     ISO Abbreviation:  Am. J. Physiol. Gastrointest. Liver Physiol.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-02     Completed Date:  2012-05-30     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  100901227     Medline TA:  Am J Physiol Gastrointest Liver Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  G645-54     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens, CD1d / genetics,  immunology
Arachis hypogaea / immunology
Aspergillus
Chemokine CCL11 / genetics,  immunology
Chemokine CCL24 / genetics,  immunology
Eosinophilic Esophagitis / etiology,  immunology*,  pathology
Esophagus / immunology,  pathology
Female
Food Hypersensitivity / complications,  immunology*
Immunoglobulin E / metabolism
Inhalation Exposure
Lymph Nodes / immunology,  physiology*
Male
Mast Cells / cytology
Mice
Mice, Inbred BALB C
Natural Killer T-Cells / physiology*
Plant Extracts / administration & dosage,  immunology
Specific Pathogen-Free Organisms
Zea mays / immunology
Grant Support
ID/Acronym/Agency:
DK067255-05S1/DK/NIDDK NIH HHS; DK078392/DK/NIDDK NIH HHS; R01 AI080581/AI/NIAID NIH HHS; R01 AI080581/AI/NIAID NIH HHS; R01 DK067255/DK/NIDDK NIH HHS; R01 DK067255/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, CD1d; 0/Ccl11 protein, mouse; 0/Ccl24 protein, mouse; 0/Chemokine CCL11; 0/Chemokine CCL24; 0/Plant Extracts; 37341-29-0/Immunoglobulin E
Comments/Corrections

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