| Significance of para-esophageal lymph nodes in food or aeroallergen-induced iNKT cell-mediated experimental eosinophilic esophagitis. | |
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MedLine Citation:
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PMID: 22207581 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Eosinophilic esophagitis (EoE) is a recently recognized inflammatory disorder driven by food hypersensitivity; however, the specific foods and mechanisms involved are unclear. In patients with EoE, we have found that hypersensitivities to corn and peanuts are the most common. Accordingly, we sensitized and exposed mice either intranasally or intragastrically with corn or peanut extract or saline. Esophageal eosinophilia, the genes of eosinophil-directed cytokines, and allergen-induced antibodies were examined in mice challenged with corn or peanut extract or saline. A high number of esophageal lamina propria eosinophils as well as eosinophilic microabscesses, intraepithelial eosinophils, extracellular eosinophilic granules, thickened and disrupted epithelial mucosa, and mast cell hyperplasia were observed in the esophagus of peanut or corn allergen-challenged mice. Mechanistic analysis indicated that para-esophageal lymph nodes might be critical in the trafficking of eosinophils to the esophagus and in EoE association to airway eosinophilia. Furthermore, experimentation with gene-targeted mice revealed that peanut allergen-induced EoE was dependent on eotaxin and invariant natural killer T (iNKT) cells, as CD1d and eotaxin-1/2 gene-deficient mice were protected from disease induction. Thus we provide evidence that para-esophageal lymph nodes are involved in food- or aeroallergen-induced eosinophilia and patchy EoE pathogenesis, likely a mechanism dependent on eotaxins and iNKT cells. |
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Authors:
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Priya Rajavelu; Madhavi Rayapudi; Matthew Moffitt; Akanksha Mishra; Anil Mishra |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-12-29 |
Journal Detail:
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Title: American journal of physiology. Gastrointestinal and liver physiology Volume: 302 ISSN: 1522-1547 ISO Abbreviation: Am. J. Physiol. Gastrointest. Liver Physiol. Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-04-02 Completed Date: 2012-05-30 Revised Date: 2013-05-06 |
Medline Journal Info:
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Nlm Unique ID: 100901227 Medline TA: Am J Physiol Gastrointest Liver Physiol Country: United States |
Other Details:
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Languages: eng Pagination: G645-54 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, CD1d / genetics, immunology Arachis hypogaea / immunology Aspergillus Chemokine CCL11 / genetics, immunology Chemokine CCL24 / genetics, immunology Eosinophilic Esophagitis / etiology, immunology*, pathology Esophagus / immunology, pathology Female Food Hypersensitivity / complications, immunology* Immunoglobulin E / metabolism Inhalation Exposure Lymph Nodes / immunology, physiology* Male Mast Cells / cytology Mice Mice, Inbred BALB C Natural Killer T-Cells / physiology* Plant Extracts / administration & dosage, immunology Specific Pathogen-Free Organisms Zea mays / immunology |
| Grant Support | |
ID/Acronym/Agency:
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DK067255-05S1/DK/NIDDK NIH HHS; DK078392/DK/NIDDK NIH HHS; R01 AI080581/AI/NIAID NIH HHS; R01 AI080581/AI/NIAID NIH HHS; R01 DK067255/DK/NIDDK NIH HHS; R01 DK067255/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD1d; 0/Ccl11 protein, mouse; 0/Ccl24 protein, mouse; 0/Chemokine CCL11; 0/Chemokine CCL24; 0/Plant Extracts; 37341-29-0/Immunoglobulin E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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