| Significance of microscopic cholangitis in alcoholic liver disease. | |
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MedLine Citation:
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PMID: 710856 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Marked biochemical cholestasis mimicking extrahepatic obstruction may occur in alcoholic liver disease. Twenty-three consecutive hyperbilirubinemic alcoholics who underwent liver biopsy were studied. Comparison of the clinical, laboratory, and histological features was made between patients with no or rare intraductal polymorphonuclear leukocytes, group A (19 cases), and those with polymorphonuclear leukocytes in multiple bile ducts ("microscopic cholangitis"), group B (4 cases). Extrahepatic biliary obstruction was excluded in group B by cholangiography. Group B had significantly higher serum SGOT, bilirubin, alkaline phosphatase, and cholesterol than group A. All group B patients had periductal acute inflammation and severe panlobular cholestasis. However, there was no significant histological difference comparing group A patients with alkaline phosphatase greater than 300 mIU per ml and group B patients, except for the presence of intraductal polymorphonuclear inflammation. Therefore, we conclude that microscopic cholangitis is a feature of severe cholestasis which may accompany alcoholic liver injury. |
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Authors:
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P Afshani; G D Littenberg; J Wollman; N Kaplowitz |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Gastroenterology Volume: 75 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1978 Dec |
Date Detail:
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Created Date: 1979-01-26 Completed Date: 1979-01-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1045-50 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Bile Ducts / pathology Cholangiography Cholangitis / complications* Cholestasis / complications Humans Liver / pathology Liver Diseases, Alcoholic / complications*, pathology, radiography Male Middle Aged |
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