Document Detail

Significance of microscopic cholangitis in alcoholic liver disease.
MedLine Citation:
PMID:  710856     Owner:  NLM     Status:  MEDLINE    
Marked biochemical cholestasis mimicking extrahepatic obstruction may occur in alcoholic liver disease. Twenty-three consecutive hyperbilirubinemic alcoholics who underwent liver biopsy were studied. Comparison of the clinical, laboratory, and histological features was made between patients with no or rare intraductal polymorphonuclear leukocytes, group A (19 cases), and those with polymorphonuclear leukocytes in multiple bile ducts ("microscopic cholangitis"), group B (4 cases). Extrahepatic biliary obstruction was excluded in group B by cholangiography. Group B had significantly higher serum SGOT, bilirubin, alkaline phosphatase, and cholesterol than group A. All group B patients had periductal acute inflammation and severe panlobular cholestasis. However, there was no significant histological difference comparing group A patients with alkaline phosphatase greater than 300 mIU per ml and group B patients, except for the presence of intraductal polymorphonuclear inflammation. Therefore, we conclude that microscopic cholangitis is a feature of severe cholestasis which may accompany alcoholic liver injury.
P Afshani; G D Littenberg; J Wollman; N Kaplowitz
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Gastroenterology     Volume:  75     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1978 Dec 
Date Detail:
Created Date:  1979-01-26     Completed Date:  1979-01-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1045-50     Citation Subset:  AIM; IM    
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MeSH Terms
Bile Ducts / pathology
Cholangitis / complications*
Cholestasis / complications
Liver / pathology
Liver Diseases, Alcoholic / complications*,  pathology,  radiography
Middle Aged

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