Document Detail


Significance of mechanical alterations in single ventricle patients on twisting and circumferential strain as determined by analysis of strain from gradient cine magnetic resonance imaging sequences.
MedLine Citation:
PMID:  20451696     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Preliminary speckle-tracking echocardiographic studies show that patients with single ventricles (SVs) have significantly decreased twisting and dyssynchrony of twisting. This could be related to abnormal cardiac looping, which leads to hearts that lack helical fiber patterns. The aim of this study was to analyze gradient cine magnetic resonance imaging (MRI) using Velocity Vector Imaging to assess cardiac mechanics. Subjects were 38 patients (aged 8 to 37 years) with SVs of left ventricular (n = 30) and indeterminate (n = 8) type who underwent cardiac MRI. Controls were 14 normal children and adults. Gradient cine MRI sequences close to the apex were subjected to a Velocity Vector Imaging analysis program adapted for MRI. In the control group, mean circumferential strain was -18.02 +/- 7.31%, mean dispersion of peak circumferential strain was 44.23 +/- 37.14 ms, and average rotation was -7.7 +/- 1.38 degrees . The rotation values were negative, or counterclockwise. In patients with SVs, mean circumferential strain was -8.87 +/- 7.30%, mean dispersion of peak circumferential strain was 181.55 +/- 76.07 ms, and average rotation was -2.6 +/- 1.24 degrees (p <0.001). Mean dispersion of the peak of rotation in the control group was 39.6 +/- 22.8 ms, compared to 166.5 +/- 72.4 ms in patients with SVs. In conclusion, this study showed a dramatic decrease in apical rotation and circumferential strain in the SV group compared to the control group. Strain and rotation mechanics at the apex in patients with SVs showed marked dyssynchrony.
Authors:
Uyen T Truong; Xiaokui Li; Craig S Broberg; Helene Houle; Michael Schaal; Muhammad Ashraf; Philip Kilner; Florence H Sheehan; Craig A Sable; Shuping Ge; David J Sahn
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Publication Detail:
Type:  Journal Article     Date:  2010-03-30
Journal Detail:
Title:  The American journal of cardiology     Volume:  105     ISSN:  1879-1913     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-10     Completed Date:  2010-06-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1465-9     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Affiliation:
Division of Cardiology, Children's National Medical Center, Washington, District of Columbia, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Cardiac Surgical Procedures / methods*
Case-Control Studies
Child
Female
Heart Bypass, Right / methods
Heart Defects, Congenital / diagnosis*,  mortality,  surgery
Heart Ventricles / abnormalities*
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging, Cine / methods*
Male
Reference Values
Risk Assessment
Sensitivity and Specificity
Survival Rate
Treatment Outcome
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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