Document Detail

Significance of the lipid profile and endothelium-dependent vasodilatation in the pathogenesis of microvascular angina.
MedLine Citation:
PMID:  18698540     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: To investigate the significance of lipid disorders and endothelial dysfunction in the pathogenesis of microvascular angina. METHODS: Levels of plasma lipids, lipoproteins and apolipoproteins were assessed in 21 patients with microvascular angina and 24 healthy subjects as controls. Also, the endothelium-dependent vasodilatation function was determined with high-resolution ultrasound in both groups. RESULTS: Levels of serum total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), apolipoprotein B(100) (ApoB(100)) and lipoprotein(a) [Lp(a)] in microvascular angina group were significantly higher than those in healthy subjects (each p < 0.05). The flow-mediated dilatation (FMD) in brachial arteries in patients with microvascular angina declined significantly as compared with that in control subjects (4.7 +/- 1.9% vs. 12.8 +/- 3.7%, p < 0.001). However, no significant difference was observed in response to nitroglycerin between groups (19.7 +/- 8.1% vs. 21.2 +/- 6.6%; p > 0.05). Linear correlation analysis revealed a significant negative correlation between the FMD of brachial arteries and the serum levels of LDL-C and Lp(a) in the microvascular angina group (r = -0.5125 and -0.4271, respectively, both p < 0.001). Subsequently, all subjects were pooled and divided into two groups (groups A and B) according to the degree of FMD in brachial arteries (A pound 4% and B > 4%). The serum LDL-C level was found to be significantly higher in group A than in group B (4.09 +/- 0.65 mmol/L vs. 2.59 +/- 0.49 mmol/L; p < 0.05). CONCLUSIONS: Plasma lipid disorders and vascular endothelial dysfunction may play important roles in the development of microvascular angina. The dysfunction of endothelium-dependent vasodilation was mainly associated with anomalies in LDL-C and Lp(a), and myocardial endothelial dysfunction was aggravated by lipid abnormalities in patients with microvascular angina.
Qi-ming Liu; Sheng-hua Zhou; Shu-shan Qi; Shui-ping Zhao; Liu Minghuib
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiology journal     Volume:  15     ISSN:  1897-5593     ISO Abbreviation:  -     Publication Date:  2008  
Date Detail:
Created Date:  2008-08-13     Completed Date:  2008-11-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101392712     Medline TA:  Cardiol J     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  324-8     Citation Subset:  IM    
Department of Cardiology, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
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MeSH Terms
Brachial Artery / physiology,  ultrasonography
Case-Control Studies
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Endothelium, Vascular / physiopathology,  ultrasonography
Follow-Up Studies
Linear Models
Lipids / blood*
Microvascular Angina / blood,  physiopathology*,  ultrasonography
Middle Aged
Multivariate Analysis
Reference Values
Risk Assessment
Severity of Illness Index
Ultrasonography, Doppler, Color
Ultrasonography, Interventional*
Vascular Resistance
Vasodilation / physiology*
Reg. No./Substance:
0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Lipids
Comment In:
Cardiol J. 2008;15(4):229-32   [PMID:  18698537 ]

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