Document Detail


Significance of lipid mediators in corneal injury and repair.
MedLine Citation:
PMID:  19965607     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Corneal injury induces an inflammatory reaction and damages the sensory nerves that exert trophic influences in the corneal epithelium. Alterations in normal healing disrupt the integrity and function of the tissue with undesirable consequences, ranging from dry eye and loss of transparency to ulceration and perforation. Lipids play important roles in this complex process. Whereas lipid mediators such as platelet activating factor (PAF) and cyclooxygenease-2 metabolites contribute to tissue damage and neovascularization, other mediators, such as the lipoxygenase (LOX) derivatives from arachidonic acid, 12- and 15-hydroxy/hydroperoxyeicosatetraenoic acids, and lipoxin A4, act as second messengers for epidermal growth factor to promote proliferation and repair. Stimulation of the cornea with pigment epithelial derived factor in the presence of docosahexaenoic acid gives rise to the synthesis of neuroprotectin D1, a derivative of LOX activity, and increases regeneration of corneal nerves. More knowledge about the role that lipids play in corneal wound healing can provide insight into the development of new therapeutic approaches for treating corneal injuries. PAF antagonists, lipoxins, and neuroprotectins can be effective therapeutic tools for maintaining the integrity of the cornea.
Authors:
Sachidananda Kenchegowda; Haydee E P Bazan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2009-11-03
Journal Detail:
Title:  Journal of lipid research     Volume:  51     ISSN:  0022-2275     ISO Abbreviation:  J. Lipid Res.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-14     Completed Date:  2010-07-07     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  0376606     Medline TA:  J Lipid Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  879-91     Citation Subset:  IM    
Affiliation:
Neuroscience Center of Excellence and Department of Ophthalmology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arachidonic Acid / chemistry,  metabolism
Cornea / injuries*,  metabolism*
Humans
Inflammation / metabolism
Lipid Metabolism*
Platelet Activating Factor / metabolism
Wound Healing*
Grant Support
ID/Acronym/Agency:
R01 EY004928/EY/NEI NIH HHS; R01 EY019465/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Platelet Activating Factor; 506-32-1/Arachidonic Acid
Comments/Corrections

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