Document Detail

Significance of left atrial pressure and left ventricular relaxation as determinants of left ventricular early diastolic filling flow in man.
MedLine Citation:
PMID:  2214134     Owner:  NLM     Status:  MEDLINE    
We analyzed the relationships among parameters of left ventricular (LV) early diastolic filling flow (EDF) obtained with pulsed Doppler echocardiography, mean pulmonary wedge pressure (PCWP) and the time constant of LV pressure fall calculated by either Weiss' (Tw) or Thompson's (Tb) method. PCWP correlated with the peak velocity (R) (r = 0.537, p less than 0.05), acceleration (Ac) (r = 0.545, p less than 0.05) and deceleration (Dc) (r = 0.606, p less than 0.01) of LVEDF. In contrast, Tb correlated only with the time to the peak of LVEDF (TPF) (r = 0.487, p less than 0.05), and Tw did not correlate with the Doppler-derived indices significantly. After correcting for the effect of PCWP, significant partial correlations between R and Tw (r = -0.535, p less than 0.05), and between Ac and both Tw (r = -0.606, p less than 0.01) and Tb (r = -0.569, p less than 0.05) were found. Dc did not correlate with Tw or Tb. These results suggest that the level of left atrial pressure may mask the relationship between parameters of LVEDF and LV relaxation, and that the relations among these variables vary with individual indices of LVEDF.
T Takahashi; M Iizuka; T Serizawa; T Ohya; H Sato; O Kohmoto; T Mochizuki; T Sakamoto; T Sugimoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese heart journal     Volume:  31     ISSN:  0021-4868     ISO Abbreviation:  Jpn Heart J     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-11-02     Completed Date:  1990-11-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401175     Medline TA:  Jpn Heart J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  319-28     Citation Subset:  IM    
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
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MeSH Terms
Atrial Function, Left*
Blood Flow Velocity
Blood Pressure
Chronic Disease
Echocardiography, Doppler
Heart Diseases / physiopathology,  ultrasonography
Middle Aged
Multivariate Analysis
Myocardial Contraction*
Pulmonary Wedge Pressure
Time Factors
Ventricular Function, Left*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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