Document Detail


Significance of keratinocyte growth factor receptor in the proliferation of biliary tract cancer.
MedLine Citation:
PMID:  21036728     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND/AIM: Biliary tract carcinoma (BTC) has extremely poor prognosis because of rapid cancer cell proliferation. The aim of this study was to clarify the significance of keratinocyte growth factor receptor (KGFR) in the proliferation of BTC.
MATERIALS AND METHODS: The expression of KGFR in 34 surgical specimens of BTC was investigated by immunohistochemical staining. The effect of Ki23057, a small synthetic molecule that interrupts the autophosphorylation of KGFR, on the proliferation of human BTC cell lines was examined in vitro and in vivo.
RESULTS: The prognosis for BTC patients with KGFR-positive tumour was significantly poorer than that for those with KGFR-negative tumour. KGF significantly stimulated the proliferation of BTC cell lines. Ki23057 significantly decreased the growth of BTC cells in vitro and in vivo.
CONCLUSION: KGFR may play an important role in the proliferation of BTC. KGFR phosphorylation inhibitor, Ki23057, therefore appears to be therapeutically promising in BTC.
Authors:
Ryosuke Amano; Nobuya Yamada; Yosuke Doi; Masakazu Yashiro; Masaichi Ohira; Atsushi Miwa; Kosei Hirakawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anticancer research     Volume:  30     ISSN:  1791-7530     ISO Abbreviation:  Anticancer Res.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-11-01     Completed Date:  2010-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  4115-21     Citation Subset:  IM    
Affiliation:
Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis / drug effects
Biliary Tract Neoplasms / genetics,  metabolism*,  pathology*
Cell Growth Processes / physiology
Cell Line, Tumor
Cell Movement / physiology
Cell Survival / drug effects
Female
Humans
Immunohistochemistry
Mice
Mice, Inbred BALB C
Mice, Nude
Phosphorylation / drug effects
Quinolines / pharmacology
RNA, Messenger / biosynthesis,  genetics
Receptor, Fibroblast Growth Factor, Type 2 / biosynthesis*,  genetics,  metabolism
Survival Rate
Transplantation, Heterologous
Chemical
Reg. No./Substance:
0/Ki23057; 0/Quinolines; 0/RNA, Messenger; EC 2.7.1.-/keratinocyte growth factor receptor; EC 2.7.10.1/Receptor, Fibroblast Growth Factor, Type 2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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