| Significance of keratinocyte growth factor receptor in the proliferation of biliary tract cancer. | |
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MedLine Citation:
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PMID: 21036728 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIM: Biliary tract carcinoma (BTC) has extremely poor prognosis because of rapid cancer cell proliferation. The aim of this study was to clarify the significance of keratinocyte growth factor receptor (KGFR) in the proliferation of BTC. MATERIALS AND METHODS: The expression of KGFR in 34 surgical specimens of BTC was investigated by immunohistochemical staining. The effect of Ki23057, a small synthetic molecule that interrupts the autophosphorylation of KGFR, on the proliferation of human BTC cell lines was examined in vitro and in vivo. RESULTS: The prognosis for BTC patients with KGFR-positive tumour was significantly poorer than that for those with KGFR-negative tumour. KGF significantly stimulated the proliferation of BTC cell lines. Ki23057 significantly decreased the growth of BTC cells in vitro and in vivo. CONCLUSION: KGFR may play an important role in the proliferation of BTC. KGFR phosphorylation inhibitor, Ki23057, therefore appears to be therapeutically promising in BTC. |
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Authors:
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Ryosuke Amano; Nobuya Yamada; Yosuke Doi; Masakazu Yashiro; Masaichi Ohira; Atsushi Miwa; Kosei Hirakawa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anticancer research Volume: 30 ISSN: 1791-7530 ISO Abbreviation: Anticancer Res. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-11-01 Completed Date: 2010-12-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: Greece |
Other Details:
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Languages: eng Pagination: 4115-21 Citation Subset: IM |
Affiliation:
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Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / drug effects Biliary Tract Neoplasms / genetics, metabolism*, pathology* Cell Growth Processes / physiology Cell Line, Tumor Cell Movement / physiology Cell Survival / drug effects Female Humans Immunohistochemistry Mice Mice, Inbred BALB C Mice, Nude Phosphorylation / drug effects Quinolines / pharmacology RNA, Messenger / biosynthesis, genetics Receptor, Fibroblast Growth Factor, Type 2 / biosynthesis*, genetics, metabolism Survival Rate Transplantation, Heterologous |
| Chemical | |
Reg. No./Substance:
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0/Ki23057; 0/Quinolines; 0/RNA, Messenger; EC 2.7.1.-/keratinocyte growth factor receptor; EC 2.7.10.1/Receptor, Fibroblast Growth Factor, Type 2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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