Document Detail


Significance of histopathology in leprosy patients with 1-5 skin lesions with relevance to therapy.
MedLine Citation:
PMID:  21701658     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Patients with 1-5 skin lesions are clinically categorized as paucibacillary for treatment purposes. For betterment and adequate treatment of patients, this grouping needs further study.
AIM: To study a group of leprosy patients with 1-5 skin lesions, compare clinical details with histopathological findings and bacteriological status of the skin to evaluate the relevance of this grouping.
MATERIALS AND METHODS: Two-year study involving 31 patients of leprosy with 1-5 skin lesions was included in this study. A number of skin lesions were recorded. Skin biopsies were taken in all patients. The biopsies were evaluated for the type of pathology and acid fast bacilli (AFB) status.
RESULTS: Of 31 patients, 19 (61.2%) had single skin lesion, 7 (22.5%) had two lesions, 4 (12.9%) had three lesions, and only one (3.22%) had four lesions, there were no patients with five lesions. Of the 31 patients, 30 (96.7%) were clinically diagnosed as borderline tuberculoid and one patient (3.22%) has tuberculoid leprosy. Skin smears were negative for AFB in all patients. The histological diagnoses were: TT 1 (3.22%), BT 24 (77.41%), and IL 6 (19.2%). AFB were found in 2 (6.45%) out of 31 skin biopsies. Clinicopathological correlation was 76.6% in the BT group.
CONCLUSION: Tissue biopsy findings in 1-5 skin lesions which were not considered relevant for treatment purposes until now should be given a status in the categorization and assessment of severity of the disease. The significance of finding of AFB and histopathology of multibacillary (MB) type of leprosy in tissue biopsies, in patients grouped as PB should be resolved so that patients could be given the drug therapy and duration of therapy they warrant.
Authors:
S Veena; Prakash Kumar; P Shashikala; H Gurubasavaraj; H R Chandrasekhar; Murugesh
Related Documents :
20107998 - Fungal rhinosinusitis: a clinicopathological study from south india.
21569098 - Filiform serrated adenomatous polyposis arising in a diverted rectum of an inflammatory...
11249088 - Sonography of acute osteomyelitis in rabbits with pathologic correlation.
1173898 - Today's scabies.
16891748 - Nasopalatine duct cyst.
15680668 - Dural cavernous angioma of the posterior sagittal sinus: case report.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of laboratory physicians     Volume:  3     ISSN:  0974-7826     ISO Abbreviation:  J Lab Physicians     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-06-24     Completed Date:  2011-07-14     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101551511     Medline TA:  J Lab Physicians     Country:  India    
Other Details:
Languages:  eng     Pagination:  21-4     Citation Subset:  -    
Affiliation:
Department of Pathology, Kasturba Medical College, Manipal, Karnataka, India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Pancytopenia: a clinico hematological study.
Next Document:  Inducible Clindamycin Resistance in Staphylococcus aureus Isolated from Clinical Samples.