Document Detail

Significance of free radical injury in laryngeal and hypopharyngeal cancers.
MedLine Citation:
PMID:  19930749     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVES: Laryngeal and hypopharyngeal cancer is a multifactorial disease caused by various carcinogens such as tobacco, alcohol and viruses. Likewise, oxidative stress is known to cause aberrations in the cell membrane and DNA, leading to cancer. We conducted this prospective study in order to evaluate the level of oxidative stress in laryngeal and hypopharyngeal cancer patients. METHODS: Fifty patients with laryngeal and hypopharyngeal cancer and 40 control subjects were selected. Serum malondialdehyde concentrations and ferric reducing antioxidant power were assessed, in order to evaluate oxidative stress. Results were analysed by Student's t-test. RESULTS: Malondialdehyde levels were significantly higher and ferric reducing antioxidant power lower in the cancer patients, compared with the controls, indicating higher oxidative stress in the former. There was no statistically significant difference in malondialdehyde concentration or ferric reducing antioxidant power, comparing patients with versus without neck secondaries, and patients with early stage versus late stage tumours. CONCLUSION: Oxidative stress may have a role to play in the initiation of laryngeal and hypopharyngeal cancers, especially in patients with other risk factors such as tobacco and alcohol use.
M K Manjunath; V Annam; D R Suresh
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Publication Detail:
Type:  Journal Article     Date:  2009-11-23
Journal Detail:
Title:  The Journal of laryngology and otology     Volume:  124     ISSN:  1748-5460     ISO Abbreviation:  J Laryngol Otol     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-16     Completed Date:  2010-05-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8706896     Medline TA:  J Laryngol Otol     Country:  England    
Other Details:
Languages:  eng     Pagination:  315-7     Citation Subset:  AIM; IM    
Department of ENT-Head and Neck Surgery, Sree Siddhartha Medical College, Tumkur, Karnataka, India.
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MeSH Terms
Alcohol Drinking / adverse effects
Antioxidants / metabolism*
Case-Control Studies
DNA Damage
Free Radicals / adverse effects
Hypopharyngeal Neoplasms / etiology,  metabolism*,  pathology
Laryngeal Neoplasms / etiology,  metabolism*,  pathology
Lipid Peroxidation / physiology
Malondialdehyde / blood*
Middle Aged
Neoplasm Staging
Oxidative Stress*
Prospective Studies
Risk Factors
Rural Health
Smoking / adverse effects
Reg. No./Substance:
0/Antioxidants; 0/Free Radicals; 542-78-9/Malondialdehyde

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