Document Detail

Significance of fetal intracardiac echogenic foci in relation to trisomy 21: a prospective sonographic study of high-risk pregnant women.
MedLine Citation:
PMID:  9530064     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of the study was to determine if an association exists between intracardiac echogenic foci in the second-trimester fetus and trisomy 21. SUBJECTS AND METHODS: Over a 2-year period, targeted fetal sonography was performed for various indications in 1593 second-trimester high-risk pregnant women. Presence or absence of echogenic foci was recorded for each fetus. Amniocentesis for karyotype analysis was performed in 901 subjects immediately after sonography. The findings of these 901 subjects formed the basis of this report. RESULTS: Intracardiac echogenic foci were present in the left ventricle of 24 (3%) of the 901 fetuses. Three (13%) of these 24 fetuses had trisomy 21; no chromosomal abnormalities were found in the other 21 fetuses. Karyotype analysis revealed trisomy 21 in 14 (2%) of the remaining 877 fetuses who did not exhibit intracardiac echogenic foci. The sensitivity, specificity, positive predictive values, and negative predictive values for intracardiac echogenic foci in predicting trisomy 21 were 18%, 98%, 13%, and 98%, respectively. The association of intracardiac echogenic foci and trisomy 21 was significant (p < .009) by the two-tailed Fisher's exact test. CONCLUSION: In a high-risk obstetric population, the association between fetal intracardiac echogenic foci and trisomy 21 was statistically significant. Therefore, women carrying fetuses with intracardiac echogenic foci should be informed of the statistical association with trisomy 21.
J E Manning; N Ragavendra; J Sayre; S L Laifer-Narin; M L Melany; E G Grant; B F Crandall
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  AJR. American journal of roentgenology     Volume:  170     ISSN:  0361-803X     ISO Abbreviation:  AJR Am J Roentgenol     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-04-16     Completed Date:  1998-04-16     Revised Date:  2008-02-15    
Medline Journal Info:
Nlm Unique ID:  7708173     Medline TA:  AJR Am J Roentgenol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1083-4     Citation Subset:  AIM; IM    
Department of Radiological Sciences, UCLA School of Medicine 90095-6969, USA.
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MeSH Terms
Down Syndrome / diagnosis,  ultrasonography*
Fetal Diseases / ultrasonography
Fetal Heart / ultrasonography*
Middle Aged
Predictive Value of Tests
Pregnancy Trimester, Second
Pregnancy, High-Risk
Prospective Studies
Sensitivity and Specificity
Ultrasonography, Prenatal*

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