| Significance of elevated thrombin-antithrombin III complex and plasmin-alpha 2-plasmin inhibitor complex in the acute stage of nontraumatic subarachnoid hemorrhage. | |
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MedLine Citation:
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PMID: 7533897 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thrombin-antithrombin III complex (TAT) and plasmin-alpha 2-plasmin inhibitor complex (PIC) were examined in the acute stage in 51 patients with nontraumatic subarachnoid hemorrhage. TAT and PIC values were correlated with severity at the time of onset and with outcome. In the patients whose TAT levels were 25 ng/ml or more and PIC levels were 3.0 micrograms/ml or more (n = 16), only 25% had a good or fair outcome. In the patients with TAT levels less than 25 ng/ml or PIC levels less than 3.0 micrograms/ml (n = 35), on the other hand, 82.9% had a good or fair outcome. There were no significant differences in TAT and PIC levels between patients who experienced arterial spasm and those who did not. These results indicate that TAT and PIC values may reflect the severity of the brain damage induced by subarachnoid hemorrhage. It is speculated that marked coagulation and fibrinolytic disorders occur in the acute stage of subarachnoid hemorrhage. |
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Authors:
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Y Itoyama; S Fujioka; S Takaki; M Morioka; T Hide; Y Ushio |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neurosurgery Volume: 35 ISSN: 0148-396X ISO Abbreviation: Neurosurgery Publication Date: 1994 Dec |
Date Detail:
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Created Date: 1995-04-13 Completed Date: 1995-04-13 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 7802914 Medline TA: Neurosurgery Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1055-60 Citation Subset: IM |
Affiliation:
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Section of Neurosurgery, Saiseikai Kumamoto Hospital, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Antifibrinolytic Agents* Antithrombin III / metabolism* Blood Coagulation Tests Brain Damage, Chronic / blood*, diagnosis Female Fibrinolysin / metabolism* Fibrinolysis Follow-Up Studies Humans Ischemic Attack, Transient / blood, diagnosis Male Middle Aged Neurologic Examination Peptide Hydrolases / metabolism* Risk Factors Subarachnoid Hemorrhage / blood*, diagnosis alpha-2-Antiplasmin / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Antifibrinolytic Agents; 0/alpha-2-Antiplasmin; 0/antithrombin III-protease complex; 0/plasmin-plasmin inhibitor complex; 9000-94-6/Antithrombin III; EC 3.4.-/Peptide Hydrolases; EC 3.4.21.7/Fibrinolysin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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