| Significance of elevated mid-trimester maternal plasma-alpha-fetoprotein values. | |
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MedLine Citation:
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PMID: 87736 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a prospective trial of 15,481 pregnancies, 667 women (4.3%) had two sequential mid-trimester plasma-alpha-fetoprotein (A.F.P.) values above 2 times the median. The outcome of these pregnancies was open neural-tube defect (12.4%), birthweight less than 2.5 kg (10.3%), twins (9.8%), fetal wastage (9.5%), perinatal death (2.6%), other (1.3%), and "normal" singleton (54.1%). At higher A.F.P. cutoffs the proportion of "normal" singleton pregnancies declined rapidly, being 19% at 3 times the median and 9% at 4 times the median. If it is assumed that ultrasonography and amniotic-fluid A.F.P. assay can detect twins and most cases of neural-tube defect, the outcome of the residual pregnancies is still strongly influenced by plasma-A.F.P. level. Thus at a cut-off of 4 times the median two-thirds of the pregnancies in this residual group will end in spontaneous abortion, stillbirth, or neonatal death. It is suggested that counselling of women taking part in A.F.P. screening programmes should be strongly influenced by maternal plasma-A.F.P. levels, even if ultrasonographic findings and amniotic-fluid levels are normal. |
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Authors:
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D J Brock; L Barron; P Duncan; J B Scrimgeour; M Watt |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Lancet Volume: 1 ISSN: 0140-6736 ISO Abbreviation: Lancet Publication Date: 1979 Jun |
Date Detail:
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Created Date: 1979-08-29 Completed Date: 1979-08-29 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985213R Medline TA: Lancet Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1281-2 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Birth Weight Congenital Abnormalities / diagnosis Female Fetal Death / diagnosis Hernia, Umbilical / diagnosis Humans Infant, Newborn Neural Tube Defects / diagnosis* Pregnancy Pregnancy Trimester, Second Pregnancy, Multiple Prenatal Diagnosis* alpha-Fetoproteins / analysis* |
| Chemical | |
Reg. No./Substance:
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0/alpha-Fetoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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