| Significance of elevated IgG anticardiolipin antibody levels in patients with Budd-Chiari syndrome. | |
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MedLine Citation:
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PMID: 9647027 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Budd-Chiari syndrome (BCS) is characterized by hepatic venous outflow obstruction. Though hypercoagulable states are implicated in the causation of BCS, the etiology remains unknown in most cases. Presence of anticardiolipin antibodies (aCL) is a known cause of hypercoagulable state. We therefore studied the frequency of IgG aCL in BCS. METHODS: Sera were obtained from 19 patients with BCS, 50 healthy controls, 18 age- and gender-matched patients with cirrhosis, and 15 patients with acute viral hepatitis. IgG aCL levels were measured using a solid-phase enzyme immunoassay. Values exceeding mean + 2 SD of healthy controls were taken as abnormal. RESULTS: Mean +/- SD IgG aCL levels (GPL units) in the four groups were: healthy controls, 6.3 +/- 4.4; BCS, 13.8 +/- 13.3 (p < 0.05, compared with healthy controls); cirrhosis, 15.1 +/- 14.9 (p < 0.05, compared with healthy controls and p = ns, compared with BCS patients); and acute viral hepatitis, 5.0 +/- 2.5 (p = ns, compared with healthy controls). The levels in BCS and cirrhosis patients were similar (p = ns). The number of patients with elevated aCL was: healthy controls, 3/50; BCS, 6/19; cirrhosis, 7/18; and acute viral hepatitis, 0/15. The number of patients with elevated IgG aCL was significantly higher among patients with BCS and cirrhosis, compared with controls (p = 0.03 and p = 0.002, respectively). CONCLUSIONS: Patients with BCS had higher IgG aCL levels than healthy controls. However, as aCL levels were also elevated in patients with cirrhosis, the pathogenetic role of IgG aCL in the causation of BCS is doubtful. |
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Authors:
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R Aggarwal; B Ravishankar; R Misra; A Aggarwal; S Dwivedi; S R Naik |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of gastroenterology Volume: 93 ISSN: 0002-9270 ISO Abbreviation: Am. J. Gastroenterol. Publication Date: 1998 Jun |
Date Detail:
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Created Date: 1998-07-13 Completed Date: 1998-07-13 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0421030 Medline TA: Am J Gastroenterol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 954-7 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adolescent Adult Antibodies, Anticardiolipin / blood* Budd-Chiari Syndrome / immunology* Child Child, Preschool Female Hepatitis, Viral, Human / immunology Humans Immunoglobulin G / analysis* Liver Cirrhosis / immunology Male Middle Aged Prospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Anticardiolipin; 0/Immunoglobulin G |
| Comments/Corrections | |
Comment In:
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Am J Gastroenterol. 1999 Jan;94(1):290
[PMID:
9934785
]
Am J Gastroenterol. 1999 Dec;94(12):3653-5 [PMID: 10606342 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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