Document Detail


Significance of dopamine metabolites in the evaluation of drugs acting on dopaminergic neurons.
MedLine Citation:
PMID:  729633     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of various drugs was studied on 3-methoxytyramine (3-MT) concentrations in rat striatum. The drugs were chosen for their ability to interfere with the dopaminergic system at different levels. Dopamine (DA) acidic metabolites, i.e. homovanillic acid (HVA) and 3,4-dihydroxyphenylacetic acid (DOPAC), were also measured. Changes of 3-MT, unlike those of DOPAC and HVA, seem to reflect the functional activity of dopaminergic neurons. In fact drugs believed to increase or decrease DA content in the synaptic cleft produce predictable changes of striatal 3-MT. Thus cocaine, nomifensine and d-amphetamine increase 3-MT concentrations while gamma-butyrolactone, alpha-methyltyrosine and apomorphine decrease it.
Authors:
A M Di Giulio; A Groppetti; F Cattabeni; C L Galli; A Maggi; S Algeri; F Ponzio
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  52     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1978 Nov 
Date Detail:
Created Date:  1979-03-13     Completed Date:  1979-03-13     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  201-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
3,4-Dihydroxyphenylacetic Acid / physiology
4-Butyrolactone / pharmacology
Animals
Apomorphine / pharmacology
Cocaine / pharmacology
Dextroamphetamine / pharmacology
Dopamine / metabolism,  physiology*
Homovanillic Acid / physiology
Male
Methyltyrosines / pharmacology
Neurons / drug effects*
Nomifensine / pharmacology
Pargyline / pharmacology
Rats
Tyramine / analogs & derivatives,  pharmacology
Chemical
Reg. No./Substance:
0/Methyltyrosines; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 24526-64-5/Nomifensine; 306-08-1/Homovanillic Acid; 50-36-2/Cocaine; 51-64-9/Dextroamphetamine; 51-67-2/Tyramine; 555-57-7/Pargyline; 58-00-4/Apomorphine; 96-48-0/4-Butyrolactone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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