Document Detail

Significance of coagulase-negative staphylococci isolated from a single blood culture from neonates in intensive care.
MedLine Citation:
PMID:  17132296     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Coagulase-negative staphylococci (CoNS) are the most common pathogens of late-onset bacteraemia in neonatal intensive care units (NICUs). Discriminating true infection from contamination is difficult. METHODS: To evaluate the significance of a single blood culture yielding CoNS from only one blood culture obtained from NICU infants between July 1999 and November 2000, paired blood cultures were obtained simultaneously from two peripheral sites from infants hospitalised in two NICUs with clinically suspected late-onset sepsis, and a single blood culture was obtained peripherally from infants hospitalised in a third NICU. Demographic data, predisposing factors, clinical manifestations, laboratory data, management and outcome of infants with either paired or single blood cultures yielding CoNS were analysed and compared. RESULTS: Both blood cultures yielded CoNS during 26 episodes in 24 infants. A single blood culture which grew CoNS from one blood culture was identified during 24 episodes in 23 infants. Except for prior use of an umbilical venous catheter, there was no significant difference between the infants with CoNS isolated from a paired or a single blood culture in terms of demographic characteristics, predisposing factors, clinical manifestations, laboratory findings, management and outcome. CONCLUSION: There was no difference in the clinical features of CoNS infection between single and paired CoNS-positive blood cultures.
Yhu-Chering Huang; Ying Hsiang Wang; Yi-Hong Chou; Rey-In Lien
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of tropical paediatrics     Volume:  26     ISSN:  0272-4936     ISO Abbreviation:  Ann Trop Paediatr     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-29     Completed Date:  2007-01-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8210625     Medline TA:  Ann Trop Paediatr     Country:  England    
Other Details:
Languages:  eng     Pagination:  311-8     Citation Subset:  IM    
Division of Pediatric Infectious Diseases, Chang Gung Children's Hospital and Chang Gung Memorial Hospital, Kweishan, Taiwan.
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MeSH Terms
Bacteremia / diagnosis,  etiology,  therapy
Birth Weight
Blood Specimen Collection / methods
Coagulase / metabolism
Cross Infection / diagnosis*,  therapy
Gestational Age
Infant, Newborn
Intensive Care Units, Neonatal
Intensive Care, Neonatal
Risk Factors
Staphylococcal Infections / diagnosis*,  etiology,  therapy,  transmission
Staphylococcus / enzymology,  isolation & purification*
Treatment Outcome
Reg. No./Substance:

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