Document Detail


Significance of the cardioprotective effect of prostanoids and indomethacin.
MedLine Citation:
PMID:  2470359     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent investigations in several organs indicate cytoprotective effects of prostanoids. For further elucidation of this efficacy the investigations dealt with the cardioprotection of prostanoids (iloprost, PGE1) and the cyclooxygenase inhibitor indomethacin under in vivo- and in vitro-conditions. The experiments were carried out in isolated perfused guinea pig hearts and anaesthetized rabbits. Cardiac damage was induced by chemical substances or loading by aortic constriction or ischemia. In isolated perfused hearts iloprost and indomethacin suppressed the toxic effects of carbon tetrachloride, chloroform, benzene, sodium dithionate and phenylethylbarbituric acid, but not the efficacy of quinine sulfate and 2,4-dinitro-phenol. Cardiac loading by aortic stenosis or ischemia induced a decrease of contractility and blood pressure and changes in the myocardial PGI2-biosynthesis. On the other side application of indomethacin, iloprost or PGE1 diminished the cardiac damage and inhibit the myocardial PGI2-formation. The results show that indomethacin and prostanoids have a protective effect in pathophysiological changes or toxic damage of the heart, possibly caused by a stabilization of the cellular membrane.
Authors:
P Mentz; K E Pawelski; C Giessler; H J Mest; M Schwab; T Kersten; E Czeslick
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Biomedica biochimica acta     Volume:  47     ISSN:  0232-766X     ISO Abbreviation:  Biomed. Biochim. Acta     Publication Date:  1988  
Date Detail:
Created Date:  1989-06-15     Completed Date:  1989-06-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8304435     Medline TA:  Biomed Biochim Acta     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  S48-51     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Toxicology, Martin Luther University Halle, GDR.
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MeSH Terms
Descriptor/Qualifier:
Alprostadil / pharmacology
Animals
Cardiotonic Agents / pharmacology*
Epoprostenol / pharmacology*
Guinea Pigs
Heart / drug effects,  physiology*
Iloprost
Indomethacin / pharmacology*
Myocardial Contraction / drug effects*
Perfusion
Reference Values
Chemical
Reg. No./Substance:
0/Cardiotonic Agents; 35121-78-9/Epoprostenol; 53-86-1/Indomethacin; 745-65-3/Alprostadil; 78919-13-8/Iloprost

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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