Document Detail

Significance of brain tissue oxygenation and the arachidonic acid cascade in stroke.
MedLine Citation:
PMID:  20673202     Owner:  NLM     Status:  MEDLINE    
The significance of the hypoxia component of stroke injury is highlighted by hypermetabolic brain tissue enriched with arachidonic acid (AA), a 22:6n-3 polyunsaturated fatty acid. In an ischemic stroke environment in which cerebral blood flow is arrested, oxygen-starved brain tissue initiates the rapid cleavage of AA from the membrane phospholipid bilayer. Once free, AA undergoes both enzyme-independent and enzyme-mediated oxidative metabolism, resulting in the formation of number of biologically active metabolites which themselves contribute to pathological stroke outcomes. This review is intended to examine two divergent roles of molecular dioxygen in brain tissue as (1) a substrate for life-sustaining homeostatic metabolism of glucose and (2) a substrate for pathogenic metabolism of AA under conditions of stroke. Recent developments in research concerning supplemental oxygen therapy as an intervention to correct the hypoxic component of stroke injury are discussed.
Cameron Rink; Savita Khanna
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2010-12-04
Journal Detail:
Title:  Antioxidants & redox signaling     Volume:  14     ISSN:  1557-7716     ISO Abbreviation:  Antioxid. Redox Signal.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-19     Completed Date:  2011-09-22     Revised Date:  2013-07-02    
Medline Journal Info:
Nlm Unique ID:  100888899     Medline TA:  Antioxid Redox Signal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1889-903     Citation Subset:  IM    
Department of Surgery, The Ohio State University Medical Center, Columbus, Ohio 43210, USA.
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MeSH Terms
Arachidonic Acid / metabolism*
Brain / metabolism*,  pathology*,  physiopathology
Brain Ischemia / metabolism,  therapy
Oxidative Stress
Oxygen / metabolism*,  therapeutic use
Stroke / metabolism*,  therapy
Grant Support
Reg. No./Substance:
506-32-1/Arachidonic Acid; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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