| Significance of brain tissue oxygenation and the arachidonic acid cascade in stroke. | |
| | |
MedLine Citation:
|
PMID: 20673202 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The significance of the hypoxia component of stroke injury is highlighted by hypermetabolic brain tissue enriched with arachidonic acid (AA), a 22:6n-3 polyunsaturated fatty acid. In an ischemic stroke environment in which cerebral blood flow is arrested, oxygen-starved brain tissue initiates the rapid cleavage of AA from the membrane phospholipid bilayer. Once free, AA undergoes both enzyme-independent and enzyme-mediated oxidative metabolism, resulting in the formation of number of biologically active metabolites which themselves contribute to pathological stroke outcomes. This review is intended to examine two divergent roles of molecular dioxygen in brain tissue as (1) a substrate for life-sustaining homeostatic metabolism of glucose and (2) a substrate for pathogenic metabolism of AA under conditions of stroke. Recent developments in research concerning supplemental oxygen therapy as an intervention to correct the hypoxic component of stroke injury are discussed. |
| | |
Authors:
|
Cameron Rink; Savita Khanna |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2010-12-04 |
Journal Detail:
|
Title: Antioxidants & redox signaling Volume: 14 ISSN: 1557-7716 ISO Abbreviation: Antioxid. Redox Signal. Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-04-19 Completed Date: 2011-09-22 Revised Date: 2012-05-15 |
Medline Journal Info:
|
Nlm Unique ID: 100888899 Medline TA: Antioxid Redox Signal Country: United States |
Other Details:
|
Languages: eng Pagination: 1889-903 Citation Subset: IM |
Affiliation:
|
Department of Surgery, The Ohio State University Medical Center, Columbus, Ohio 43210, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Arachidonic Acid / metabolism* Brain / metabolism*, pathology*, physiopathology Brain Ischemia / metabolism, therapy Humans Oxidative Stress Oxygen / metabolism*, therapeutic use Stroke / metabolism*, therapy |
| Grant Support | |
ID/Acronym/Agency:
|
NS42617/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
506-32-1/Arachidonic Acid; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Chart review of patients on valsartan-based single-pill combinations vs. ARB-based free combinations...
Next Document: Lipid signaling in the atherogenesis context.