| Significance of blood coagulation and platelet profiles in relation to pulmonary thrombosis in beta-thalassemia/Hb E. | |
| | |
MedLine Citation:
|
PMID: 7777905 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In beta-Thalassemia hemoglobin E (beta-thal Hb E), hypoxemia with abnormal lung function was described and postmortem examination in these patients showed organized pulmonary trombi with thickened arterial wall, particularly in post-splenectomized cases. Coagulation and platelet profiles were studied in 58 beta-thal Hb E patients. In 35 cases with intact spleen, the fibrinolytic activity was significantly decreased with high antithrombin III activity, while coagulation tests revealed mild abnormality. The platelet aggregation to ADP, adrenaline, collagen and ristocretin were defective and platelet 5-hydroxytryptamine content was lower than normal. Twenty-three patients who had been splenectomized for 5-18 years, decreased fibrinolytic activity and high antithrombin III activity were also observed. The coagulation profiles and platelet aggregation in response to ADP, adrenaline and collagen showed better results. Fourteen cases exhibited thrombocytosis and their thrombin generation was in the hypercoagulable range. Platelet aggregation in response to ristocetin remained defective and platelet 5-hydroxytryptamine content was lower than in cases with intact spleens. Defective aggregation to ristocetin would indicate abnormal von Willebrand's factor (vWF). Decreased fibrinolysis should very likely have a role in the occurrence of thrombosis and the better hemostatic profiles in post-splenectomized cases would contribute to the more frequent thrombotic incidence in these cases. |
| | |
Authors:
|
S Visudhiphan; K Ketsa-Ard; S Tumliang; A Piankijagum |
Related Documents
:
|
11914655 - Evaluation of the blood coagulation mechanism and platelet aggregation in individuals w... 12071575 - Platelet membrane glycoproteins in haemostasis. 18024615 - Hypercoagulability in sickle cell disease: new approaches to an old problem. 13679655 - The insulin resistance syndrome: implications for thrombosis and cardiovascular disease. 6183925 - Platelet activation in response to phlebotomy. an experimental study of healthy blood d... 9045345 - A review of the pharmacokinetics and pharmacodynamics of combination carboplatin/paclit... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Southeast Asian journal of tropical medicine and public health Volume: 25 ISSN: 0125-1562 ISO Abbreviation: Southeast Asian J. Trop. Med. Public Health Publication Date: 1994 Sep |
Date Detail:
|
Created Date: 1995-07-11 Completed Date: 1995-07-11 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0266303 Medline TA: Southeast Asian J Trop Med Public Health Country: THAILAND |
Other Details:
|
Languages: eng Pagination: 449-56 Citation Subset: IM |
Affiliation:
|
Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Aged, 80 and over Antithrombin III / metabolism Blood Coagulation* Blood Platelets / metabolism Female Fibrinolysis Hemoglobin E* Humans Male Middle Aged Platelet Aggregation* Platelet Count Pulmonary Embolism / etiology* Serotonin / blood Splenectomy beta-Thalassemia / blood, complications* |
| Chemical | |
Reg. No./Substance:
|
50-67-9/Serotonin; 9000-94-6/Antithrombin III; 9034-61-1/Hemoglobin E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Exotoxin profiles of Campylobacters isolated in Malaysia.
Next Document: The increasing importance of vitamin B12 deficiency as a contributing factor to anemia in Malaysia.