Document Detail


Significance of blood coagulation and platelet profiles in relation to pulmonary thrombosis in beta-thalassemia/Hb E.
MedLine Citation:
PMID:  7777905     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In beta-Thalassemia hemoglobin E (beta-thal Hb E), hypoxemia with abnormal lung function was described and postmortem examination in these patients showed organized pulmonary trombi with thickened arterial wall, particularly in post-splenectomized cases. Coagulation and platelet profiles were studied in 58 beta-thal Hb E patients. In 35 cases with intact spleen, the fibrinolytic activity was significantly decreased with high antithrombin III activity, while coagulation tests revealed mild abnormality. The platelet aggregation to ADP, adrenaline, collagen and ristocretin were defective and platelet 5-hydroxytryptamine content was lower than normal. Twenty-three patients who had been splenectomized for 5-18 years, decreased fibrinolytic activity and high antithrombin III activity were also observed. The coagulation profiles and platelet aggregation in response to ADP, adrenaline and collagen showed better results. Fourteen cases exhibited thrombocytosis and their thrombin generation was in the hypercoagulable range. Platelet aggregation in response to ristocetin remained defective and platelet 5-hydroxytryptamine content was lower than in cases with intact spleens. Defective aggregation to ristocetin would indicate abnormal von Willebrand's factor (vWF). Decreased fibrinolysis should very likely have a role in the occurrence of thrombosis and the better hemostatic profiles in post-splenectomized cases would contribute to the more frequent thrombotic incidence in these cases.
Authors:
S Visudhiphan; K Ketsa-Ard; S Tumliang; A Piankijagum
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Southeast Asian journal of tropical medicine and public health     Volume:  25     ISSN:  0125-1562     ISO Abbreviation:  Southeast Asian J. Trop. Med. Public Health     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1995-07-11     Completed Date:  1995-07-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0266303     Medline TA:  Southeast Asian J Trop Med Public Health     Country:  THAILAND    
Other Details:
Languages:  eng     Pagination:  449-56     Citation Subset:  IM    
Affiliation:
Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Antithrombin III / metabolism
Blood Coagulation*
Blood Platelets / metabolism
Female
Fibrinolysis
Hemoglobin E*
Humans
Male
Middle Aged
Platelet Aggregation*
Platelet Count
Pulmonary Embolism / etiology*
Serotonin / blood
Splenectomy
beta-Thalassemia / blood,  complications*
Chemical
Reg. No./Substance:
50-67-9/Serotonin; 9000-94-6/Antithrombin III; 9034-61-1/Hemoglobin E

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