| Significance of atypical cervical cytology in pregnancy. | |
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MedLine Citation:
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PMID: 1418129 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To ascertain the significance of squamous atypia encountered during routine Papanicolaou smear screening in pregnancy, we reviewed our experience with 76 pregnant women seen during a 4-year period. All were evaluated with repeat cytology and colposcopy during pregnancy and again postpartum. Colposcopic examination during pregnancy revealed a normal transformation zone without evidence of intraepithelial neoplasia in 46 women. In six of these women, repeat cytology was interpreted as cervical intraepithelial neoplasia (CIN) grade 1. In 30 women, an abnormal transformation zone was identified--14 with a negative repeat cytology. In five women, the transformation zone was interpreted as compatible with CIN 2 or CIN 3. Colposcopically directed biopsies were performed in 31 women, in all but two postpartum. Of the 76 women, human papilloma virus or CIN was identified on biopsy in 16 women (21%). We propose that an isolated report of atypical squamous cells on cervical cytology obtained at the initial prenatal visit does not warrant colposcopic evaluation during pregnancy, unless a repeat cytology suggests CIN. Repeat cytology and evaluation to exclude infections and inflammatory lesions is appropriate. However, if a subsequent cytology is abnormal, postpartum colposcopy and colposcopically directed biopsies seem appropriate, since the prevalence of HPV or CIN was 21%. |
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Authors:
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P F Kaminski; D S Lyon; J I Sorosky; J B Wheelock; E S Podczaski |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: American journal of perinatology Volume: 9 ISSN: 0735-1631 ISO Abbreviation: Am J Perinatol Publication Date: 1992 Sep-Nov |
Date Detail:
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Created Date: 1992-12-16 Completed Date: 1992-12-16 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8405212 Medline TA: Am J Perinatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 340-3 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Carcinoma in Situ
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pathology* Carcinoma, Squamous Cell / pathology* Cell Transformation, Neoplastic / pathology* Colposcopy Female Humans Postpartum Period Pregnancy Pregnancy Complications, Neoplastic / pathology* Retrospective Studies Tumor Virus Infections / pathology* Uterine Cervical Neoplasms / pathology* Vaginal Smears |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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