Document Detail

Significance of antithrombin III, protein C and protein S in acute mesenteric ischemia patients.
MedLine Citation:
PMID:  15154576     Owner:  NLM     Status:  MEDLINE    
It is well established that a condition of hypercoagulation due to deficiencies of antithrombin III, protein C and protein S may result in thrombo-embolism. To evaluate the possibility of hypercoagulation in acute mesenteric ischemia (AMI); clinical features, ECG changes, drug history, the length of intestine remaining after the resection and mortality of 15 consecutive patients were recorded and plasma levels of antithrombin III, Protein C and protein S were measured. Antihypertensive, antidiabetic and digitalis were the main drugs used by the patients. Atrial fibrillation was the main ECG finding (60%). AMI was attributed to thrombo-embolic phenomena because of atrial fibrillation in these patients. Levels of antithrombin III and protein S were lower in patients without atrial fibrillation compared to those with the condition (mean values 16.18 vs. 18.04 and 87.33 vs. 94.22 respectively) but the difference was not statistically significant. Levels of Protein C were lower and the length of intestine remaining after resection was shorter in patients without, compared to those with, atrial fibrillation (mean values 77.00 vs. 88.66, and 52.5 cm vs. 86.11 cm respectively). The difference was statistically significant (p < 0.05). Postoperative mortality rate was 33.3% (5 patients) and the length of intestine remaining after resection was the main determining factor in the prognosis of the patients. We conclude that a condition of hypercoagulation due to a deficiency of protein C has a significant role in the pathogenesis of AMI especially in patients without atrial fibrillation.
N Ağaoğlu; S Türkyilmaz; C Ozlü; M K Arslan; E Colak
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta chirurgica Belgica     Volume:  104     ISSN:  0001-5458     ISO Abbreviation:  Acta Chir. Belg.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-05-24     Completed Date:  2004-09-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370571     Medline TA:  Acta Chir Belg     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  184-6     Citation Subset:  IM    
Karadeniz Technical University, Faculty of Medicine, Department of General Surgery, Trabzon, Turkey.
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MeSH Terms
Acute Disease
Aged, 80 and over
Antithrombin III / analysis
Atrial Fibrillation / complications
Blood Proteins / analysis*
Embolism / etiology
Intestinal Diseases / blood,  etiology*
Ischemia / blood,  etiology*
Mesenteric Artery, Superior
Mesenteric Veins
Mesentery / blood supply*
Middle Aged
Protein C / analysis
Protein S / analysis
Thrombophilia / blood,  complications*
Thrombosis / etiology
Reg. No./Substance:
0/Blood Proteins; 0/Protein C; 0/Protein S; 9000-94-6/Antithrombin III

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