Document Detail

Significance of antinuclear antibodies and rheumatoid factor in patients with advanced peripheral arterial disease.
MedLine Citation:
PMID:  20357501     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether or not elevated titers of antinuclear antibodies (ANA) and/or rheumatoid factor (RF) are associated with patients with advanced peripheral arterial disease (PAD). SUBJECTS AND METHODS: A cross-sectional study was done between September 2005 and December 2006. Fifty-eight patients with clinical and angiographic evidence of PAD and 41 controls were studied. Controls had no documented history of peripheral, coronary or cerebral vascular disease. All subjects were screened for metabolic syndrome and C-reactive protein (CRP) as risk factors for peripheral vascular disease. Additionally, all were tested for anti-mitochondrial, anti-neutrophil cytoplasmic and anti-smooth muscle antibodies; those with positive results were excluded. ANA and RF were measured in sera from cases and controls. RESULTS: One case and 3 controls had positive anti-smooth muscle antibodies and were therefore excluded from statistical analysis. Metabolic syndrome was significantly more prevalent in patients than controls (p<0.05). Mean CRP level was 4.78+/-7.70 and 2.65+/-3.86 mg/dl in cases and controls, respectively (p=0.021). ANA were detected at a titer of >or=1:40 in 6 (10.5%) of the advanced PAD patients but none of the controls; the difference was not statistically significant. RF was less prevalent in cases than controls (p<0.05). CONCLUSION: RF and ANA do not appear to be associated with PAD in a Kuwaiti population.
Laila R Qadan; Adel A Ahmed; Suhair Abdel-Jalil; Marzouk A Al-Bader
Publication Detail:
Type:  Journal Article     Date:  2010-03-29
Journal Detail:
Title:  Medical principles and practice : international journal of the Kuwait University, Health Science Centre     Volume:  19     ISSN:  1423-0151     ISO Abbreviation:  Med Princ Pract     Publication Date:  2010  
Date Detail:
Created Date:  2010-04-01     Completed Date:  2010-06-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8901334     Medline TA:  Med Princ Pract     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  192-5     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 S. Karger AG, Basel.
Department of Medicine-Endocrinology, Kuwait University, and Department of Surgery, Mubarak Al-Kabeer Hospital, Ministry of Health, Kuwait.
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MeSH Terms
Antibodies, Antinuclear / blood*
Autoantibodies / blood
Blood Glucose / analysis
C-Reactive Protein / analysis
Cross-Sectional Studies
Lipids / blood
Middle Aged
Peripheral Vascular Diseases / blood,  immunology*
Rheumatoid Factor / blood*
Reg. No./Substance:
0/Antibodies, Antinuclear; 0/Autoantibodies; 0/Blood Glucose; 0/Lipids; 9007-41-4/C-Reactive Protein; 9009-79-4/Rheumatoid Factor

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