| Significance of abnormal myocardial perfusion scintigraphy in young adult patients with SLE. | |
| | |
MedLine Citation:
|
PMID: 19728017 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: Detection of subclinical coronary artery disease (CAD) is a potential challenge in patients with systemic lupus erythematosus (SLE) and it is suggested that myocardial perfusion single photon emission computerized tomography (SPECT) is more sensitive than exercise test in this setting. However, the significance of perfusion abnormalities in SLE patients is not well known. In this study, we evaluated the prognostic significance of myocardial perfusion defects in patients with SLE. METHODS: Patients with proven diagnosis of SLE admitted to the hospital due to noncardiac problems with no history of CAD were studied. All patients underwent (99m)Tc-MIBI myocardial perfusion scan using dipyridamole as pharmacological stress. All patients were followed up by reviewing patients file in lupus clinic and any minor or major cardiac events were recorded. RESULTS: Eighteen female and two male patients with mean age of 28.2 +/- 12.05 years were included. Six patients had mild reversible perfusion defects with mean summed difference score of 2.5 +/- 1.0. Pattern of reverse redistribution (reverse fill-in) was noted in three patients. Eleven patients had normal myocardial perfusion. Hypokinesia was noted in three patients on gated images. One patient with abnormal perfusion died 21 days after imaging due to non-cardiac cause. Nineteen patients were followed for a mean time of 39.2 +/- 16.0 months. No major or minor cardiac events were noted during follow-up. Three patients (one with abnormal perfusion) had at least one readmission during follow-up period. CONCLUSION: Our study showed that myocardial perfusion abnormalities are fairly frequent in SLE patients but the defects are generally mild and do not advocate an adverse prognosis. |
| | |
Authors:
|
Seyed Rasoul Zakavi; Mohammad Hasan Jokar; Vahid Reza Dabbagh Kakhki; Ghodsieh Khazaei; Ramin Sadeghi |
Related Documents
:
|
17893967 - Vascular elasticity of systemic lupus erythematosus patients is associated with steroid... 9008597 - Long-term treatment of systemic lupus erythematosus with cyclosporin a. 8774177 - Quantitative nailfold capillaroscopy findings in a population with connective tissue di... 1234407 - Nervous system involvement in systemic lupus erythematosus. 18594197 - Bone mineral density in patients with parkinson's disease. 12352477 - Female gender does not protect blunt trauma patients from complications and mortality. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-08-29 |
Journal Detail:
|
Title: Annals of nuclear medicine Volume: 23 ISSN: 1864-6433 ISO Abbreviation: Ann Nucl Med Publication Date: 2009 Oct |
Date Detail:
|
Created Date: 2010-01-29 Completed Date: 2010-05-11 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8913398 Medline TA: Ann Nucl Med Country: Japan |
Other Details:
|
Languages: eng Pagination: 725-8 Citation Subset: IM |
Affiliation:
|
Department of Nuclear Medicine, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Coronary Circulation Female Humans Lupus Erythematosus, Systemic / diagnosis, physiopathology, radionuclide imaging* Male Middle Aged Myocardial Perfusion Imaging* Prognosis Retrospective Studies Tomography, Emission-Computed, Single-Photon Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Orthopedic surgery-related benign uptake on FDG-PET: case examples and pitfalls.
Next Document: Vasodilatory effect of adenosine triphosphate does not change cerebral blood flow: a PET study with ...