Document Detail

The significance of serum AFP cut-off values, 20 and 400 ng/mL in curatively resected patients with hepatocellular carcinoma and cirrhosis might be of difference.
MedLine Citation:
PMID:  22469729     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: The significance of preoperative serum a-fetoprotein (AFP) level in hepatocellular carcinoma (HCC) treated with different modalities remains controversial. Besides, many cut-off values have been used. The present study aims to clarify significance of two major ones in HCC with cirrhosis.
METHODOLOGY: One hundred and thirty eight consecutive cirrhotic patients with HCC after curative resection are included. The correlations between serum AFP level and clinicopathological parameters and patient survival are evaluated and compared when 400ng/mL and 20ng/mL are set as cut-off points.
RESULTS: Serum AFP level is associated with more clinicopathological variables of HCC under the cut-off value of 400ng/mL, than that of 20ng/ mL. However, serum AFP level under the cut-off value of 20ng/mL is of significant prognostic impact for both overall and tumor-free survival, whereas that under 400ng/mL is not.
CONCLUSIONS: The two cut-off values of preoperative AFP levels might be of different implications in cirrhotic patients with HCC after curative resection. Therefore, these might be adopted differentially in HCC.
Li Zhou; Jing-An Rui; Shao-Bin Wang; Shu-Guang Chen; Qiang Qu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  59     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-03     Completed Date:  2012-07-02     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  840-3     Citation Subset:  IM    
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MeSH Terms
Carcinoma, Hepatocellular / blood*,  etiology,  mortality,  surgery*
Chi-Square Distribution
Disease-Free Survival
Hepatectomy* / adverse effects,  mortality
Kaplan-Meier Estimate
Liver Cirrhosis / blood*,  complications,  mortality
Liver Neoplasms / blood*,  etiology,  mortality,  surgery*
Logistic Models
Middle Aged
Predictive Value of Tests
Time Factors
Treatment Outcome
alpha-Fetoproteins / analysis*
Reg. No./Substance:
0/AFP protein, human; 0/alpha-Fetoproteins

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