Significance of QRS morphology in determining the prevalence of mechanical dyssynchrony in heart failure patients eligible for cardiac resynchronization: particular focus on patients with right bundle branch block with and without coexistent left-sided conduction defects.

Significance of QRS morphology in determining the prevalence of mechanical dyssynchrony in heart failure patients eligible for cardiac resynchronization: particular focus on patients with right bundle branch block with and without coexistent left-sided conduction defects.

MedLine Citation:	PMID: 18390536 Owner: NLM Status: MEDLINE
Abstract/OtherAbstract:	AIMS: The aim of this study was to assess the significance of QRS morphology in determining the prevalence of mechanical dyssynchrony in heart failure (HF) patients considered eligible for cardiac resynchronization. METHODS AND RESULTS: A total of 200 consecutive HF patients (158 males, mean age 56 +/- 13.5 years) with standard indications for cardiac resynchronization therapy (CRT) were evaluated prospectively. The prevalence of an interventricular mechanical delay > or = 40 ms was lower in patients with pure right bundle branch block (RBBB) than that in those with RBBB plus left fascicular hemiblock (RBBB-LFH) and those with left bundle branch block (LBBB) (33 vs. 50 vs. 54%, P = 0.05). A maximal difference in peak myocardial systolic velocity among all 12 segments (Ts) > 100 ms was found in 63% of the patients with LBBB, whereas it was present in 31% of the patients with pure RBBB and in 42% of those with RBBB-LFH (P < 0.001). A standard deviation of Ts (Ts-SD) > 34 ms was present in 58% of the LBBB subjects, but in only 29% and 42% of the patients with pure RBBB and RBBB-LFH, respectively (P < 0.001). Intraventricular dyssynchrony, however, was not different in patients with pure RBBB and in those with RBBB-LFH in terms of maximal difference in Ts (P = 0.25) and Ts-SD (P = 0.17). CONCLUSIONS: Although LBBB was more often associated with intraventricular dyssynchrony, ECG sign of additional left ventricular (LV) conduction delay is not a helpful tool for the identification of intra-LV mechanical dyssynchrony in HF patients with RBBB who would benefit from CRT.

Authors:	Majid Haghjoo; Ataallah Bagherzadeh; Maryam Moshkani Farahani; Zahra Ojaghi Haghighi; Mohammad Ali Sadr-Ameli
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Publication Detail:	Type: Clinical Trial; Journal Article Date: 2008-04-03
Journal Detail:	Title: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology Volume: 10 ISSN: 1532-2092 ISO Abbreviation: Europace Publication Date: 2008 May
Date Detail:	Created Date: 2008-04-29 Completed Date: 2008-05-28 Revised Date: -
Medline Journal Info:	Nlm Unique ID: 100883649 Medline TA: Europace Country: England
Other Details:	Languages: eng Pagination: 566-71 Citation Subset: IM
Affiliation:	Department of Pacemaker and Electrophysiology, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, PO Box 15745-1341, Mellat Park, Vali-E-Asr Avenue, Tehran 1996911151, Iran. majid.haghjoo@gmail.com
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MeSH Terms
Descriptor/Qualifier:	Bundle-Branch Block / diagnosis, epidemiology, prevention & control Defibrillators, Implantable / statistics & numerical data* Electrocardiography / methods* Female Heart Failure / diagnosis, prevention & control Humans Iran / epidemiology Male Middle Aged Patient Selection* Prevalence Reproducibility of Results Sensitivity and Specificity Ventricular Dysfunction, Left / diagnosis, epidemiology, prevention & control

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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