Document Detail

Significance of measuring S100A12 and sRAGE in the serum of sepsis patients with postoperative acute lung injury.
MedLine Citation:
PMID:  20689292     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: There is a report that S100A12 is useful as an early marker of acute lung injury (ALI). The purpose of this study was to determine whether S100A12 or sRAGE is useful as a marker during the development of ALI in postoperative sepsis patients.
METHODS: The subjects were patients who underwent emergency surgery because of sepsis secondary to perforation of the lower gastrointestinal tract. We conducted a retrospective study comparing 2 groups of patients: a group of 9 patients who developed postoperative ALI, the ALI(+) group, and a group of 8 patients who did not develop postoperative ALI, the ALI(-) group. Their blood S100A12, sRAGE, IFN-gamma, WBC count, and CRP values were measured immediately after surgery and on postoperative day 1 (D1).
RESULTS: The changes in S100A12 showed significantly higher values immediately postoperatively in the ALI(+) group (p < 0.05). The sRAGE values immediately postoperatively were similar, but on D1, they were significantly higher in the ALI(-) group (p < 0.05).
CONCLUSIONS: S100A12 increases in the early stage of development of ALI. sRAGE production increases in patients who do not develop ALI.
Tomohiro Kikkawa; Nobuhiro Sato; Masahiro Kojika; Gaku Takahashi; Kiichi Aoki; Koichi Hoshikawa; Shinji Akitomi; Tatsuyori Shozushima; Kenji Suzuki; Go Wakabayashi; Shigeatsu Endo
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-31
Journal Detail:
Title:  Digestive surgery     Volume:  27     ISSN:  1421-9883     ISO Abbreviation:  Dig Surg     Publication Date:  2010  
Date Detail:
Created Date:  2010-08-27     Completed Date:  2010-12-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501808     Medline TA:  Dig Surg     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  307-12     Citation Subset:  IM    
Copyright Information:
Copyright 2010 S. Karger AG, Basel.
Department of Critical Care Medicine, Iwate Medical University, School of Medicine, Morioka, Japan.
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MeSH Terms
Acute Lung Injury / blood*,  etiology,  mortality
Aged, 80 and over
Biological Markers / blood
Cohort Studies
Critical Illness
Follow-Up Studies
Middle Aged
Peritonitis / complications,  mortality,  surgery
Postoperative Complications / blood,  mortality
Receptors, Immunologic / blood*
Retrospective Studies
Risk Assessment
S100 Proteins / blood*
Sensitivity and Specificity
Sepsis / blood*,  etiology,  mortality,  surgery*
Statistics, Nonparametric
Survival Analysis
Treatment Outcome
Reg. No./Substance:
0/Biological Markers; 0/Receptors, Immunologic; 0/S100 Proteins; 0/S100A12 protein, human; 0/advanced glycosylation end-product receptor

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