| Significance of measuring S100A12 and sRAGE in the serum of sepsis patients with postoperative acute lung injury. | |
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MedLine Citation:
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PMID: 20689292 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: There is a report that S100A12 is useful as an early marker of acute lung injury (ALI). The purpose of this study was to determine whether S100A12 or sRAGE is useful as a marker during the development of ALI in postoperative sepsis patients. METHODS: The subjects were patients who underwent emergency surgery because of sepsis secondary to perforation of the lower gastrointestinal tract. We conducted a retrospective study comparing 2 groups of patients: a group of 9 patients who developed postoperative ALI, the ALI(+) group, and a group of 8 patients who did not develop postoperative ALI, the ALI(-) group. Their blood S100A12, sRAGE, IFN-gamma, WBC count, and CRP values were measured immediately after surgery and on postoperative day 1 (D1). RESULTS: The changes in S100A12 showed significantly higher values immediately postoperatively in the ALI(+) group (p < 0.05). The sRAGE values immediately postoperatively were similar, but on D1, they were significantly higher in the ALI(-) group (p < 0.05). CONCLUSIONS: S100A12 increases in the early stage of development of ALI. sRAGE production increases in patients who do not develop ALI. |
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Authors:
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Tomohiro Kikkawa; Nobuhiro Sato; Masahiro Kojika; Gaku Takahashi; Kiichi Aoki; Koichi Hoshikawa; Shinji Akitomi; Tatsuyori Shozushima; Kenji Suzuki; Go Wakabayashi; Shigeatsu Endo |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-31 |
Journal Detail:
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Title: Digestive surgery Volume: 27 ISSN: 1421-9883 ISO Abbreviation: Dig Surg Publication Date: 2010 |
Date Detail:
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Created Date: 2010-08-27 Completed Date: 2010-12-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8501808 Medline TA: Dig Surg Country: Switzerland |
Other Details:
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Languages: eng Pagination: 307-12 Citation Subset: IM |
Copyright Information:
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Copyright 2010 S. Karger AG, Basel. |
Affiliation:
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Department of Critical Care Medicine, Iwate Medical University, School of Medicine, Morioka, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Lung Injury
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blood*,
etiology,
mortality Aged Aged, 80 and over Biological Markers / blood Cohort Studies Critical Illness Female Follow-Up Studies Humans Male Middle Aged Peritonitis / complications, mortality, surgery Postoperative Complications / blood, mortality Receptors, Immunologic / blood* Retrospective Studies Risk Assessment S100 Proteins / blood* Sensitivity and Specificity Sepsis / blood*, etiology, mortality, surgery* Statistics, Nonparametric Survival Analysis Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Receptors, Immunologic; 0/S100 Proteins; 0/S100A12 protein, human; 0/advanced glycosylation end-product receptor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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