Document Detail

Significance and management of proteinuria in kidney transplant recipients.
MedLine Citation:
PMID:  19820126     Owner:  NLM     Status:  MEDLINE    
Proteinuria is common after kidney transplantation and typically urine protein levels are below 500 mg/d. However, even these low levels are associated with reduced graft survival. Most allografts with proteinuria >1500 mg/d have new glomerular pathology. In contrast, lower levels of proteinuria are generally associated with nonglomerular, nonspecific histologic changes. The relationship between proteinuria and graft survival is independent of other variables, including graft function and graft histology. Thus, proteinuria allows stratification of risk in patients with or without glomerular pathology. Proteinuria should be monitored periodically posttransplant and investigation of the cause should be pursued vigorously.
Hatem Amer; Fernando G Cosio
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-10-09
Journal Detail:
Title:  Journal of the American Society of Nephrology : JASN     Volume:  20     ISSN:  1533-3450     ISO Abbreviation:  J. Am. Soc. Nephrol.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-01     Completed Date:  2009-12-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9013836     Medline TA:  J Am Soc Nephrol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2490-2     Citation Subset:  IM    
Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA.
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MeSH Terms
Calcineurin / antagonists & inhibitors
Graft Survival
Immunosuppressive Agents / adverse effects
Kidney Failure, Chronic / complications,  surgery
Kidney Transplantation / adverse effects*
Proteinuria / etiology*,  therapy*
Sirolimus / adverse effects
Reg. No./Substance:
0/Immunosuppressive Agents; 53123-88-9/Sirolimus; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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