| Significance of DC-LAMP and DC-SIGN expression in psoriasis vulgaris lesions. | |
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MedLine Citation:
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PMID: 21596034 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: To detect and compare the expression levels of two dendritic cell proteins, namely Dendritic Cell Lysosome-Associated Membrane Protein (DC-LAMP) and Dendritic Cell-Specific ICAM-3 Grabbing Non-integrin (DC-SIGN) in psoriasis vulgaris lesions and normal skin tissues. METHODS: We used Reverse Transcription-Polymerase Chain Reaction (RT-PCR) and immunohistochemical analysis to detect the expression of DC-LAMP and DC-SIGN in 33 samples representing plaque lesions of psoriasis vulgaris and 11 normal skin samples from healthy volunteers. RESULTS: RT-PCR The expression levels of DC-LAMP and DC-SIGN were higher in samples of psoriasis vulgaris lesions than in that of normal skin, based on RT-PCR results.Whereas DC-LAMP staining was mostly cytoplasmic in keratinocytes of basal and spinous epidermis and dermal dendritic cells, DC-SIGN staining was both cytoplasmic and nuclear in keratinocytes of spinous epidermis and dermal dendritic cells. The expression levels of DC-LAMP and DC-SIGN proteins were significantly higher in psoriasis vulgaris lesions when compared with normal skin tissues (P<0.01). Furthermore, we found a positive correlation between high DC-LAMP and high DC-SIGN expression levels in psoriasis vulgaris lesions (P<0.05, r=0.368). CONCLUSION: Compared with normal tissues, the levels of DC-LAMP and DC-SIGN were higher in psoriasis vulgaris lesions. Both DC-LAMP and DC-SIGN proteins may be involved in the pathogenesis of psoriasis vulgaris. The high expression of DC-LAMP may be associated with the altered differentiation of keratynocytes in psoriasis. |
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Authors:
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Ma Wei-Yuan; Liu Wen-Ting; Zhao Chen; Sun Qing |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-6 |
Journal Detail:
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Title: Experimental and molecular pathology Volume: - ISSN: 1096-0945 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370711 Medline TA: Exp Mol Pathol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Dermatology, Qilu Hospital, Shandong University, Jinan 250012, China; Institution of Pathology, School of Medicine, Shandong University, Jinan 250012, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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