Document Detail


Significance of the anatomical properties of a myocardial bridge in coronary heart disease.
MedLine Citation:
PMID:  21467656     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A myocardial bridge (MB), partially covering the coronary artery, is a congenital anatomical variant usually present in the left anterior descending coronary artery (LAD). MB causes coronary heart disease (CHD) by 2 distinct mechanisms influenced by the anatomical properties of the MB, such as its length, thickness, and location. One is direct MB compression of the LAD at cardiac systole, resulting in delayed arterial relaxation at diastole, reduced blood flow reserve, and decreased blood perfusion. The other is enhancement of coronary atherosclerosis causing stenosis of the LAD proximal to the MB, occurring because of endothelial injury arising from the abnormal hemodynamics provoked by retrograde blood flow up toward the left coronary ostium at cardiac systole. The magnitude of the effect of the 2 distinct mechanisms of the MB on LAD blood flow is prescribed by a common root of the MB-muscle mass volume generated by those properties. Furthermore, the anatomical properties of the MB are closely associated with the choice of treatment and therapeutic outcome in CHD patients having an MB. Thus, the anatomical properties of an MB should be considered in the diagnosis and management of CHD patients with this anomaly.
Authors:
Yukio Ishikawa; Yoko Kawawa; Eiichi Kohda; Kazuyuki Shimada; Toshiharu Ishii
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2011-03-31
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  75     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2011  
Date Detail:
Created Date:  2011-06-24     Completed Date:  2012-01-18     Revised Date:  2012-01-26    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1559-66     Citation Subset:  IM    
Affiliation:
Department of Pathology, Toho University School of Medicine, Tokyo, Japan. yukio@med.toho-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Antagonists / therapeutic use
Cardiovascular Surgical Procedures
Coronary Disease / pathology*,  physiopathology*
Coronary Vessel Anomalies / pathology,  physiopathology
Coronary Vessels / pathology,  physiopathology
Humans
Myocardial Bridging / pathology*,  physiopathology*,  therapy
Regional Blood Flow / physiology
Stents
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists

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