Document Detail

Signet-ring cell melanoma mimicking adenocarcinoma. A case report.
MedLine Citation:
PMID:  8328253     Owner:  NLM     Status:  MEDLINE    
The fine needle aspiration findings in a lymph node involved by signet-ring cell melanoma, a very rare variant of malignant melanoma, are reported. The patient had a history of superficial spreading melanoma of the right foot, treated 10 years earlier by below-the-knee amputation. He presented with a right groin mass. Fine needle aspiration of the mass yielded poorly cohesive, large cells with eccentric nuclei and abundant, eosinophilic cytoplasm; many of them exhibited a signet-ring appearance. Melanin pigments were identified in a small proportion of tumor cells, and a diagnosis of metastatic melanoma was made. The subsequent lymph node excision revealed a metastatic tumor composed of polygonal and signet-ring cells that were positive for S-100 protein and HMB-45 but not cytokeratin. Nearly all reported cases of signet-ring cell melanoma occurred as metastatic or recurrent disease. It is important not to mistake signet-ring cell melanoma for adenocarcinoma in aspiration cytology, and a constellation of clinical features and of histochemical and immunohistochemical findings enables a correct diagnosis to be reached.
W Y Tsang; J K Chan; L T Chow
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta cytologica     Volume:  37     ISSN:  0001-5547     ISO Abbreviation:  Acta Cytol.     Publication Date:    1993 Jul-Aug
Date Detail:
Created Date:  1993-08-10     Completed Date:  1993-08-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370307     Medline TA:  Acta Cytol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  559-62     Citation Subset:  IM    
Institute of Pathology, Queen Elizabeth Hospital, Kowloon, Hong Kong.
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MeSH Terms
Adenocarcinoma / pathology*
Aged, 80 and over
Biopsy, Needle
Diagnosis, Differential
Immunoenzyme Techniques
Lymphatic Metastasis / pathology*,  ultrastructure
Melanoma / pathology*,  ultrastructure

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