Document Detail

Signet ring cell melanocytic nevus: report of a case over trichilemmal cyst and review of the literature.
MedLine Citation:
PMID:  22262365     Owner:  NLM     Status:  In-Data-Review    
Different melanocytic nevi have been reported as being associated with dermal cysts. Signet ring cell melanocytic nevus is a rare variant of melanocytic nevus characterized by cells with signet ring morphology within a common melanocytic nevus. This article describes an exceptional case of melanocytic nevus composed exclusively of signet ring cells over a trichilemmal cyst. Histologically, above the cyst, there was a small, symmetrical and sharply demarcated lesion showing a compound proliferation of small, round, monomorphous cells with signet ring morphology. Immunohistochemically, signet ring cells were negative for cytokeratin AE1/3, leukocyte common antigen, HMB-45, and CD34. Occasionally, isolated signet ring cells were positive for S-100 and melan A. Melanocytic nevus composed of signet ring cells should raise the differential diagnosis with other cutaneous tumors exhibiting signet ring cells. Previous cases of this entity reported in the literature are also reviewed.
Vicente Sabater Marco; Begoña Escutia Muñoz; Arturo Morera Faet; Rafael Botella Estrada
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American Journal of dermatopathology     Volume:  34     ISSN:  1533-0311     ISO Abbreviation:  Am J Dermatopathol     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911005     Medline TA:  Am J Dermatopathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e10-4     Citation Subset:  IM    
From the *Department of Pathology, University General Hospital, Valencia, Spain; †Department of Dermatology, University Hospital La Fe, Valencia, Spain; and ‡Department of Pathology, Hospital Casa de Salud, Valencia, Spain.
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