Document Detail

Signet ring basal cell carcinoma. A case study emphasizing the differential diagnosis of neoplasms with signet ring cell formation.
MedLine Citation:
PMID:  11795835     Owner:  NLM     Status:  MEDLINE    
Signet ring cells are cells in which the nucleus is crescentically compressed to the cellular border so that the cells look like signet rings. Due to the pluripotential nature of the basal cells of the epidermis, basal cell carcinoma displays many histopathological variants. We herein report the rare case of a middle-aged woman who had a basal cell carcinoma on the skin of the upper lip. The neoplasm was predominantly composed of cells with signet ring configuration. Histochemically, the latter were mucin-negative. Immunohistochemistry demonstrated intracytoplasmic reactivity for cytokeratin MNF116 with strong staining intensity, as well as for smooth muscle actin. The signet ring tumor cells were S100 protein-negative and carcinoembryonic antigen-negative. The lack of ploidy abnormality as well as of molecular alterations in K-ras and p53 genes may explain in part the non-aggressive biological behavior of the present tumor. Because of potential diagnostic difficulties, the pathologist should be aware of this unusual form of basal cell carcinoma. A brief review of the literature on the differential diagnosis of signet ring cell cutaneous tumors is presented.
K Aroni; A C Lazaris; I Nikolaou; A Saetta; N Kavantzas; P S Davaris
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pathology, research and practice     Volume:  197     ISSN:  0344-0338     ISO Abbreviation:  Pathol. Res. Pract.     Publication Date:  2001  
Date Detail:
Created Date:  2002-01-17     Completed Date:  2002-06-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7806109     Medline TA:  Pathol Res Pract     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  853-6     Citation Subset:  IM    
Department of Pathology, School of Medicine, The National and Capodistrian University of Athens, Greece.
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MeSH Terms
Adenocarcinoma / secondary
Breast Neoplasms / secondary
Carcinoma, Basal Cell / chemistry,  genetics,  pathology*
Carcinoma, Signet Ring Cell / chemistry,  genetics,  pathology*
Carcinoma, Squamous Cell / pathology
DNA, Neoplasm / analysis
Diagnosis, Differential
Image Cytometry
Image Processing, Computer-Assisted
Lymphoma / pathology
Middle Aged
Neoplasm Proteins / analysis
Skin Neoplasms / chemistry,  genetics,  pathology*
Treatment Outcome
Tumor Markers, Biological / analysis
Reg. No./Substance:
0/DNA, Neoplasm; 0/Neoplasm Proteins; 0/Tumor Markers, Biological
Erratum In:
Pathol Res Pract 2002;198(1):64

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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