Document Detail


Signature microRNA expression profile of essential hypertension and its novel link to human cytomegalovirus infection.
MedLine Citation:
PMID:  21690488     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Essential hypertension has been recognized as a disease resulting from a combination of environmental and genetic factors. Recent studies demonstrated that microRNAs (miRNAs) are involved in cardiac hypertrophy and heart failure. However, little is known about the roles of miRNAs in essential hypertension.
METHODS AND RESULTS: Using microarray-based miRNA expression profiling, we compared the miRNA expressions in plasma samples from 13 hypertensive patients and 5 healthy control subjects. Twenty-seven miRNAs were found to be differentially expressed. The expressions of selected miRNAs (miR-296-5p, let-7e, and a human cytomegalovirus [HCMV]-encoded miRNA, hcmv-miR-UL112) were validated independently in plasma samples from 24 hypertensive patients and 22 control subjects. The absolute expression levels of hcmv-miR-UL112, miR-296-5p, and let-7e were further determined in 127 patients and 67 control subjects (fold changes are 2.5, 0.5, and 1.7 respectively; all P<0.0001). Additionally, we demonstrated that interferon regulatory factor 1 is a direct target of hcmv-miR-UL112. Increased HCMV seropositivity and quantitative titers were found in the hypertension group compared with the control group (52.7% versus 30.9%, P=0.0005; 1870 versus 54 copies per 1 mL plasma, P<0.0001). Seropositivity, log-transformed copies of HCMV, and hcmv-miR-UL112 were independently associated with an increased risk of hypertension (odds ratio, 2.48; 95% confidence interval, 1.48 to 4.15; P=0.0005; odds ratio, 1.97; 95% confidence interval, 1.58 to 2.46; P<0.0001; and odds ratio, 2.55; 95% confidence interval, 1.98 to 3.27; P<0.0001, respectively).
CONCLUSIONS: We report for the first time a circulating miRNA profile for hypertensive patients and demonstrate a novel link between HCMV infection and essential hypertension. These findings may reveal important insights into the pathogenesis of essential hypertension.
CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. UNIQUE IDENTIFIER: NCT00420784.
Authors:
Shuqiang Li; Jianguo Zhu; Weili Zhang; Youren Chen; Ke Zhang; Laurentiu M Popescu; Xinliang Ma; Wayne Bond Lau; Rong Rong; Xueqing Yu; Bingbing Wang; Yafeng Li; Chuanshi Xiao; Mingming Zhang; Shuyan Wang; Liping Yu; Alex F Chen; Xinchun Yang; Jun Cai
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-06-20
Journal Detail:
Title:  Circulation     Volume:  124     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-12     Completed Date:  2011-09-08     Revised Date:  2012-03-12    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  175-84     Citation Subset:  AIM; IM    
Affiliation:
Department of Cardiology, Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00420784
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Cohort Studies
Cytomegalovirus / metabolism*
Cytomegalovirus Infections / blood*,  complications
Female
Gene Expression Profiling
Gene Expression Regulation
Humans
Hypertension / blood*,  etiology
Male
MicroRNAs / blood*
Middle Aged
Oligonucleotide Array Sequence Analysis
RNA, Viral / blood*
Risk Factors
Chemical
Reg. No./Substance:
0/MicroRNAs; 0/RNA, Viral
Comments/Corrections
Comment In:
Circulation. 2012 Feb 7;125(5):e337; author reply e338-9   [PMID:  22311889 ]

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