Document Detail

Signals mediating skeletal muscle remodeling by resistance exercise: PI3-kinase independent activation of mTORC1.
MedLine Citation:
PMID:  21071597     Owner:  NLM     Status:  MEDLINE    
For over 10 years, we have known that the activation of the mammalian target of rapamycin complex 1 (mTORC1) has correlated with the increase in skeletal muscle size and strength that occurs following resistance exercise. Initial cell culture and rodent models of muscle growth demonstrated that the activation of mTORC1 is common to hypertrophy induced by growth factors and increased loading. The further observation that high loads increased the local production of growth factors led to the paradigm that resistance exercise stimulates the autocrine production of factors that act on membrane receptors to activate mTORC1, and this results in skeletal muscle hypertrophy. Over the last few years, there has been a paradigm shift. From both human and rodent studies, it has become clear that the phenotypic and molecular responses to resistance exercise occur in a growth factor-independent manner. Although the mechanism of load-induced mTORC1 activation remains to be determined, it is clear that it does not require classical growth factor signaling.
Andrew Philp; D Lee Hamilton; Keith Baar
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Publication Detail:
Type:  Journal Article     Date:  2010-11-11
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  110     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-09     Completed Date:  2011-06-07     Revised Date:  2013-09-30    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  561-8     Citation Subset:  IM    
1 Shields Ave., 174 Briggs Hall, Univ. of California, Davis, CA 95616, USA.
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MeSH Terms
Models, Biological*
Muscle, Skeletal / physiology*
Phosphatidylinositol 3-Kinases / metabolism*
Proteins / metabolism*
Signal Transduction / physiology*
Reg. No./Substance:
0/Proteins; 0/mechanistic target of rapamycin complex 1; EC 2.7.1.-/Phosphatidylinositol 3-Kinases
Comment In:
J Appl Physiol (1985). 2011 Jan;110(1):256-7   [PMID:  21088204 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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