Document Detail


Signals from the deep: reach-related activity in the human superior colliculus.
MedLine Citation:
PMID:  23035097     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neurophysiological studies in nonhuman species indicated that neurons in the superior colliculus (SC) are involved in the control of upper limb movements. These findings suggested that the SC represents a crucial hub in a general sensorimotor network, including skeletomotor as much as oculomotor functions. In contrast to the SC in the various animal models, the human SC is largely unknown territory. In particular, it is unknown whether findings of reach-related activity in the nonhuman SC can be extrapolated to humans. Using fMRI we found signal increases at superficial/intermediate and deep locations at the SC during the execution of arm movements. In contrast, signals related to saccade execution were confined to the superficial and intermediate locations. Although targets for reaching were presented in the left and right hemifields under central fixation, we found a lateralization of reach-related signals with respect to the active arm. In contrast, saccade-related activity was bilateral, in agreement with the bilateral target presentation and the resulting directions of saccades. Our results suggest that the human SC not only contributes to the coordination of eye movements and spatial shifts of attentions but also to the sensorimotor control of arm movements.
Authors:
Walter Linzenbold; Marc Himmelbach
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  32     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-04     Completed Date:  2013-01-17     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  13881-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Arm / physiology*
Female
Hand / physiology
Humans
Magnetic Resonance Imaging / methods
Male
Movement / physiology*
Photic Stimulation
Psychomotor Performance / physiology
Reaction Time / physiology
Saccades / physiology
Superior Colliculi / physiology*
Young Adult
Grant Support
ID/Acronym/Agency:
211078//European Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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