| Signals consistent with microbubbles detected in legs of normal human subjects after exercise. | |
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MedLine Citation:
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PMID: 19875715 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Exercise may produce micronuclei (presumably gas-filled bubbles) in tissue, which could serve as nucleation sites for bubbles during subsequent decompression stress. These micronuclei have never been directly detected in humans. Dual-frequency ultrasound (DFU) is a resonance-based, ultrasound technique capable of detecting and sizing small stationary bubbles. We surveyed for bubbles in the legs of six normal human subjects (ages 28-52 yr) after exercise using DFU. Eleven marked sites on the left thigh and calf were imaged using standard imaging ultrasound. Subjects then rested in a reclining chair for 2 h before exercise. For the hour before exercise, a series of baseline measurements was taken at each site using DFU. At least six baseline measurements were taken at each site. Subjects exercised at 80% of their age-adjusted maximal heart rate for 30 min on an upright bicycle ergometer. After exercise, the subjects returned to the chair, and multiple postexercise measurements were taken at the marked sites. Measurements continued until no further signals consistent with bubbles were returned or 1 h had elapsed. All subjects showed signals consistent with bubbles after exercise at at least one site. The percentage of sites in a given subject showing signals significantly greater than baseline (P < 0.01) at first measurement ranged from 9.1 to 100%. Overall, 58% of sites showed signals consistent with bubbles at the first postexercise measurement. Signals decreased over time after exercise. These data strongly suggest that exercise produces bubbles detectable using DFU. |
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Authors:
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J C Wilbur; S D Phillips; T G Donoghue; D L Alvarenga; D A Knaus; P J Magari; J C Buckey |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. Date: 2009-10-29 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 108 ISSN: 1522-1601 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-01 Completed Date: 2010-04-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 240-4 Citation Subset: IM |
Affiliation:
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Creare Inc., Hanover, New Hampshire, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Decompression Sickness / physiopathology, ultrasonography Exercise / physiology* Gases / blood* Humans Knee / physiology, ultrasonography Leg / physiology*, ultrasonography* Male Middle Aged Signal Processing, Computer-Assisted Thigh / physiology, ultrasonography Transducers |
| Chemical | |
Reg. No./Substance:
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0/Gases |
| Comments/Corrections | |
Comment In:
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J Appl Physiol. 2010 Feb;108(2):238-9
[PMID:
20019159
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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