| Signalling through FOXP3 as an X-linked tumor suppressor. | |
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MedLine Citation:
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PMID: 20678582 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The FOXP3 (forkhead box P3) gene is a member of forkhead winged helix family transcription factors and functions as both a transcriptional activator and a repressor. FOXP3 dysfunction is responsible for an X-linked autoimmune syndrome: immune dysregulation, polyendopathy, enterophathy, X-linked syndrome. In addition to its role as an essential transcription factor in regulatory T cells, the FOXP3 gene is an epithelial cell-intrinsic tumor suppressor for breast and prostate cancers. We will focus on the FOXP3 signalling pathway in epithelial cells and discuss how genetic and/or epigenetic inactivation of the FOXP3 contributes to the malignant transformation of cells. |
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Authors:
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Hiroto Katoh; Pan Zheng; Yang Liu |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review Date: 2010-08-01 |
Journal Detail:
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Title: The international journal of biochemistry & cell biology Volume: 42 ISSN: 1878-5875 ISO Abbreviation: Int. J. Biochem. Cell Biol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-05 Completed Date: 2011-01-18 Revised Date: 2011-11-01 |
Medline Journal Info:
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Nlm Unique ID: 9508482 Medline TA: Int J Biochem Cell Biol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1784-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Division of Immunotherapy, Department of Surgery, University of Michigan School of Medicine and Cancer Center, Ann Arbor, MI 48109, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Breast Neoplasms / genetics, metabolism Female Forkhead Transcription Factors / genetics, metabolism* Genes, Tumor Suppressor / physiology Genes, X-Linked / genetics*, physiology Humans Male Prostatic Neoplasms / genetics, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA120901-04/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Forkhead Transcription Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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