Document Detail

Signalling pathways that mediate skeletal muscle hypertrophy and atrophy.
MedLine Citation:
PMID:  12563267     Owner:  NLM     Status:  MEDLINE    
Atrophy of skeletal muscle is a serious consequence of numerous diseases, including cancer and AIDS. Successful treatments for skeletal muscle atrophy could either block protein degradation pathways activated during atrophy or stimulate protein synthesis pathways induced during skeletal muscle hypertrophy. This perspective will focus on the signalling pathways that control skeletal muscle atrophy and hypertrophy, including the recently identified ubiquitin ligases muscle RING finger 1 (MuRF1) and muscle atrophy F-box (MAFbx), as a basis to develop targets for pharmacologic intervention in muscle disease.
David J Glass
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nature cell biology     Volume:  5     ISSN:  1465-7392     ISO Abbreviation:  Nat. Cell Biol.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-02-03     Completed Date:  2003-03-27     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  100890575     Medline TA:  Nat Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  87-90     Citation Subset:  IM    
Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591-6707, USA.
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MeSH Terms
1-Phosphatidylinositol 3-Kinase / metabolism
Calcineurin / metabolism
Hypertrophy / metabolism
Insulin-Like Growth Factor I / metabolism
Ligases / metabolism
Muscle Proteins / metabolism
Muscle, Skeletal / metabolism*,  pathology*
Muscular Atrophy / metabolism*
Protein-Serine-Threonine Kinases*
Proto-Oncogene Proteins / metabolism
Proto-Oncogene Proteins c-akt
Receptors, Adrenergic, beta-2 / metabolism
SKP Cullin F-Box Protein Ligases*
Signal Transduction / physiology*
Ubiquitin-Protein Ligases*
Reg. No./Substance:
0/Muscle Proteins; 0/Proto-Oncogene Proteins; 0/Receptors, Adrenergic, beta-2; 67763-96-6/Insulin-Like Growth Factor I; EC 3-Kinase; EC Kinases; EC Proteins c-akt; EC; EC 6.-/Ligases; EC protein, human; EC Cullin F-Box Protein Ligases; EC protein, human; EC Ligases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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