Document Detail


Signalling pathways that control vertebrate haematopoietic stem cell specification.
MedLine Citation:
PMID:  23618830     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Haematopoietic stem cells (HSCs) are tissue-specific stem cells that replenish all mature blood lineages during the lifetime of an individual. Clinically, HSCs form the foundation of transplantation-based therapies for leukaemias and congenital blood disorders. Researchers have long been interested in understanding the normal signalling mechanisms that specify HSCs in the embryo, in part because recapitulating these requirements in vitro might provide a means to generate immune-compatible HSCs for transplantation. Recent embryological work has demonstrated the existence of previously unknown signalling requirements. Moreover, it is now clear that gene expression in the nearby somite is integrally involved in regulating the transition of the embryonic endothelium to a haemogenic fate. Here, we review current knowledge of the intraembryonic signals required for the specification of HSCs in vertebrates.
Authors:
Wilson K Clements; David Traver
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Nature reviews. Immunology     Volume:  13     ISSN:  1474-1741     ISO Abbreviation:  Nat. Rev. Immunol.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-26     Completed Date:  2013-06-24     Revised Date:  2014-10-01    
Medline Journal Info:
Nlm Unique ID:  101124169     Medline TA:  Nat Rev Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  336-48     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation / immunology
Cell Lineage
Hematopoiesis / immunology*
Hematopoietic Stem Cells / cytology,  immunology*
Regenerative Medicine / methods
Signal Transduction
Vertebrates
Grant Support
ID/Acronym/Agency:
R00 HL097150/HL/NHLBI NIH HHS; R01 DK074482/DK/NIDDK NIH HHS; R01 DK074482‑06/DK/NIDDK NIH HHS
Comments/Corrections

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