| Signalling mechanisms mediating neuronal responses to guidance cues. | |
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MedLine Citation:
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PMID: 14682358 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several families of extracellular guidance cues have been implicated in guiding neurons and axons to their appropriate destinations in the nervous system. Their receptors include single- and seven-transmembrane receptors, and their signal transduction pathways converge onto the Rho family of small GTPases, which control the cytoskeleton. A single guidance protein can use different mechanisms to regulate different kinds of motility or the motilities of different cell types. There is crosstalk between the signalling pathways initiated by distinct guidance cues. Studies of neuronal guidance mechanisms have shed light not only on neural development, but also on other processes that involve the extracellular regulation of the cytoskeleton. |
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Authors:
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Kun-Liang Guan; Yi Rao |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Nature reviews. Neuroscience Volume: 4 ISSN: 1471-003X ISO Abbreviation: Nat. Rev. Neurosci. Publication Date: 2003 Dec |
Date Detail:
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Created Date: 2003-12-18 Completed Date: 2004-01-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100962781 Medline TA: Nat Rev Neurosci Country: England |
Other Details:
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Languages: eng Pagination: 941-56 Citation Subset: IM |
Affiliation:
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Life Sciences Institute, Department of Biological Chemistry and Institute of Gerontology, University of Michigan, Ann Arbor, Michigan 48109, USA. kunliang@umich.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Axons / physiology Cell Movement / physiology Humans Neurons / physiology* Receptor Cross-Talk / physiology Receptors, Cell Surface / physiology Signal Transduction / physiology* rho GTP-Binding Proteins / physiology |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Cell Surface; EC 3.6.5.2/rho GTP-Binding Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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