Document Detail


Signalling mechanisms involved in volume regulation of intestinal epithelial cells.
MedLine Citation:
PMID:  11125207     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Most mammalian cells have developed compensatory mechanisms to respond to the variable osmotic stress caused by changes in the concentrations of intracellular osmo-active substances (e.g. glucose, amino acids, lactate) or by variations in the osmolarity of the surrounding medium. In response to osmotic cell swelling, the Regulatory Volume Decrease (RVD) is triggered and directs a reduction in the tonicity of the cell by the concerted opening of cation and anion selective ion channels. To date, the K(+) and Cl(-) conductances activated upon hypo-osmotic stimulation have been characterised electrophysiologically in many different cell systems. The molecular identity of the channels however, as well as the mechanism(s) involved in their activation have not yet been fully clarified and may differ between cell types. In this review, we will evaluate the different signalling pathways activated by osmotic cell swelling and discuss their putative role(s) in ion channel regulation, in maintaining cellular volume homeostasis, and in auto- and paracrinic signal transduction, with emphasis on intestinal epithelial cells.
Authors:
T van der Wijk ; S F Tomassen; H R de Jonge ; B C Tilly
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology     Volume:  10     ISSN:  1015-8987     ISO Abbreviation:  Cell. Physiol. Biochem.     Publication Date:  2000  
Date Detail:
Created Date:  2001-01-26     Completed Date:  2001-03-22     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9113221     Medline TA:  Cell Physiol Biochem     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  289-96     Citation Subset:  IM    
Copyright Information:
Copyright 2000 S. Karger AG, Basel.
Affiliation:
Department of Biochemistry, Cardiovascular Research Institute COEUR, Faculty of Medicine and Health Sciences, Erasmus University Rotterdam, Rotterdam, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Size*
Epithelial Cells / metabolism
Humans
Intestines / cytology,  metabolism*
Signal Transduction*

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