| Signaling via the kinase p38α programs dendritic cells to drive T(H)17 differentiation and autoimmune inflammation. | |
| | |
MedLine Citation:
|
PMID: 22231518 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Dendritic cells (DCs) bridge innate and adaptive immunity, but how DC-derived signals regulate T cell lineage choices remains unclear. We report here that the mitogen-activated protein kinase p38α programmed DCs to drive the differentiation of the T(H)17 subset of helper T cells. Deletion of p38α in DCs protected mice from T(H)17 cell-mediated autoimmune neuroinflammation, but deletion of p38α in macrophages or T cells did not. We also found that p38α orchestrated the expression of cytokines and costimulatory molecules in DCs and further 'imprinted' signaling via the receptor for interleukin 23 (IL-23R) in responding T cells to promote T(H)17 differentiation. Moreover, p38α was required for tissue-infiltrating DCs to sustain T(H)17 responses. This activity of p38α was conserved in mouse and human DCs and was dynamically regulated by pattern recognition and fungal infection. Our results identify p38α signaling as a central pathway for the integration of instructive signals in DCs for T(H)17 differentiation and inflammation. |
| | |
Authors:
|
Gonghua Huang; Yanyan Wang; Peter Vogel; Thirumala-Devi Kanneganti; Kinya Otsu; Hongbo Chi |
Related Documents
:
|
12811798 - Specific roles of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide-induced f... 12435978 - The role of cyclooxygenase-2 in lumbar disc herniation. 6949878 - Prostaglandin generation by separated human blood mononuclear cell fractions. 9596548 - Scientific rationale for specific inhibition of cox-2. 17907378 - Potent and selective inhibition of tat-dependent hiv-1 replication in chronically infec... 20394798 - Both nramp1 and dmt1 are necessary for efficient macrophage iron recycling. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-08 |
Journal Detail:
|
Title: Nature immunology Volume: - ISSN: 1529-2916 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-10 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100941354 Medline TA: Nat Immunol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: NLRC4 inflammasomes in dendritic cells regulate noncognate effector function by memory CD8(+) T cell...
Next Document: The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macro...