| Signaling via the MyD88 adaptor protein in B cells suppresses protective immunity during Salmonella typhimurium infection. | |
| | |
MedLine Citation:
|
PMID: 21093317 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The myeloid differentiation primary response gene 88 (Myd88) is critical for protection against pathogens. However, we demonstrate here that MyD88 expression in B cells inhibits resistance of mice to Salmonella typhimurium infection. Selective deficiency of Myd88 in B cells improved control of bacterial replication and prolonged survival of the infected mice. The B cell-mediated suppressive pathway was even more striking after secondary challenge. Upon vaccination, mice lacking Myd88 in B cells became completely resistant against this otherwise lethal infection, whereas control mice were only partially protected. Analysis of immune defenses revealed that MyD88 signaling in B cells suppressed three crucial arms of protective immunity: neutrophils, natural killer cells, and inflammatory T cells. We further show that interleukin-10 is an essential mediator of these inhibitory functions of B cells. Collectively, our data identify a role for MyD88 and B cells in regulation of cellular mechanisms of protective immunity during infection. |
| | |
Authors:
|
Patricia Neves; Vicky Lampropoulou; Elisabeth Calderon-Gomez; Toralf Roch; Ulrik Stervbo; Ping Shen; Anja A Kühl; Christoph Loddenkemper; Matthias Haury; Sergei A Nedospasov; Stefan H E Kaufmann; Ulrich Steinhoff; Dinis P Calado; Simon Fillatreau |
Related Documents
:
|
9284827 - Lymphocyte apoptosis during early phase of listeria infection in mice. 20204057 - Upregulation of salmonella-induced il-6 production in caco-2 cells by pj-34, parp-1 inh... 16925787 - Cholesterol is required to trigger caspase-1 activation and macrophage apoptosis after ... 11755407 - Cytokines in host defense against salmonella. 15688297 - Fibronectin-binding proteins and fibrinogen-binding clumping factors play distinct role... 17102587 - Autophagic-like cell death in neutrophils induced by autoantibodies. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Immunity Volume: 33 ISSN: 1097-4180 ISO Abbreviation: Immunity Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-11-24 Completed Date: 2010-12-30 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9432918 Medline TA: Immunity Country: United States |
Other Details:
|
Languages: eng Pagination: 777-90 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
|
Deutsches Rheuma-Forshungszentrum, a Leibniz institute, Charitéplatz 1, 10117 Berlin, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals B-Lymphocytes / immunology* Immunity, Innate Interleukin-10 / immunology Killer Cells, Natural / immunology Lymphocytes / immunology Mice Mice, Inbred C57BL Myeloid Differentiation Factor 88 / genetics, metabolism* Neutrophils / immunology Salmonella Infections, Animal / immunology* Salmonella Vaccines / immunology Salmonella typhimurium / immunology* Signal Transduction / immunology* |
| Chemical | |
Reg. No./Substance:
|
0/Myd88 protein, mouse; 0/Myeloid Differentiation Factor 88; 0/Salmonella Vaccines; 130068-27-8/Interleukin-10 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cell-cell propagation of NF-?B transcription factor and MAP kinase activation amplifies innate immun...
Next Document: Regulated expression of nuclear receptor ROR?t confers distinct functional fates to NK cell receptor...