Document Detail


Signaling and transcriptional control of pancreatic organogenesis.
MedLine Citation:
PMID:  12200159     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The results of several new studies encourage a revision of fundamental hypotheses concerning the cellular and molecular mechanisms underlying pancreatic morphogenesis and cell differentiation in the embryo. The roles of FGF- and BMP-signaling indicate a fundamental difference in the induction of the dorsal and the ventral pancreatic anlage. Final commitment to the pancreatic fate requires the action of several transcriptional regulators including IPF1/PDX1, PBX1 and PTF1-P48 after the onset of pancreatic bud formation. Two, largely independent endocrine cell lineages develop during the formation of the embryonic pancreas. Lineage tracing has begun to refine our understanding of the origins of the acinar, ductal and islet cells.
Authors:
Seung K Kim; Raymond J MacDonald
Related Documents :
20551619 - New insights into endocrine pancreatic development: the role of environmental factors.
1980759 - Pancreatic cell proliferation in normal rats studied by in vivo autoradiography with 3h...
389429 - Pancreatic endocrine cells of barbus conchonius (teleostei, cyprinidae), and their rela...
20965759 - Ff1b, the sf1 ortholog, is important for pancreatic islet cell development in zebrafish.
2192239 - Do the pancreatic primordial buds in embryogenesis have the potential to produce all pa...
3315789 - 64,000-mr autoantigen in type i diabetes. evidence against its surface location on huma...
15752729 - Functional characterization of a conditionally immortalized mouse epididymis caput epit...
10444519 - Effects of tnf-alpha and il-1beta on iron metabolism by a549 cells and influence on cyt...
19003319 - The cytotoxic effect of eucheuma serra agglutinin (esa) on cancer cells and its applica...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Current opinion in genetics & development     Volume:  12     ISSN:  0959-437X     ISO Abbreviation:  Curr. Opin. Genet. Dev.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-08-29     Completed Date:  2003-03-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9111375     Medline TA:  Curr Opin Genet Dev     Country:  England    
Other Details:
Languages:  eng     Pagination:  540-7     Citation Subset:  IM    
Affiliation:
Departments of Developmental Biology and Medicine (Oncology Division), Stanford UniversityStanford, California, 94305-5329, USA. seungkim@stanford.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation
Gene Expression Regulation
Humans
Morphogenesis
Pancreas / embryology*,  growth & development*
Signal Transduction / physiology*
Transcription Factors / physiology*
Transcription, Genetic / physiology*
Grant Support
ID/Acronym/Agency:
DK 55226/DK/NIDDK NIH HHS; DK 56709/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Transcription Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Signaling and transcriptional control of pituitary development.
Next Document:  Developmental regulation of somite derivatives: muscle, cartilage and tendon.