Document Detail

Signaling and transcriptional control of pancreatic organogenesis.
MedLine Citation:
PMID:  12200159     Owner:  NLM     Status:  MEDLINE    
The results of several new studies encourage a revision of fundamental hypotheses concerning the cellular and molecular mechanisms underlying pancreatic morphogenesis and cell differentiation in the embryo. The roles of FGF- and BMP-signaling indicate a fundamental difference in the induction of the dorsal and the ventral pancreatic anlage. Final commitment to the pancreatic fate requires the action of several transcriptional regulators including IPF1/PDX1, PBX1 and PTF1-P48 after the onset of pancreatic bud formation. Two, largely independent endocrine cell lineages develop during the formation of the embryonic pancreas. Lineage tracing has begun to refine our understanding of the origins of the acinar, ductal and islet cells.
Seung K Kim; Raymond J MacDonald
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Current opinion in genetics & development     Volume:  12     ISSN:  0959-437X     ISO Abbreviation:  Curr. Opin. Genet. Dev.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-08-29     Completed Date:  2003-03-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9111375     Medline TA:  Curr Opin Genet Dev     Country:  England    
Other Details:
Languages:  eng     Pagination:  540-7     Citation Subset:  IM    
Departments of Developmental Biology and Medicine (Oncology Division), Stanford UniversityStanford, California, 94305-5329, USA.
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MeSH Terms
Cell Differentiation
Gene Expression Regulation
Pancreas / embryology*,  growth & development*
Signal Transduction / physiology*
Transcription Factors / physiology*
Transcription, Genetic / physiology*
Grant Support
Reg. No./Substance:
0/Transcription Factors

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